UCMA gene expression is stimulated by RUNX2 and SP7

Stable Identifier
R-HSA-8939870
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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UCMA gene expression is stimulated by RUNX2 and SP7
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While RUNX2 and SP7 (OSX), based on mouse studies, can stimulate the UCMA gene expression independently of each other, simultaneous binding of RUNX2 and SP7 to adjacent RUNX2 and SP7 binding sites, respectively, in the UCMA promoter, synergistically activates UCMA transcription. UCMA stimulates osteoblast differentiation and formation of mineralized nodules (Lee et al. 2015).
Literature References
PubMed ID Title Journal Year
25865393 Ucma, a direct transcriptional target of Runx2 and Osterix, promotes osteoblast differentiation and nodule formation

Lee, SJ, Park, SY, Kim, JE, Boo, YC, Lee, YJ, Choi, JY

Osteoarthr. Cartil. 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX2:CBFB:SP7:UCMA gene [nucleoplasm] (Homo sapiens)
Active Unit
SP7 [nucleoplasm]
RUNX2:CBFB [nucleoplasm]
Inferred From
Ucma gene expression is stimulated by Runx2 and Sp7 (Mus musculus)
Authored
Orlic-Milacic, M  (2016-09-21)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-21)
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