UCMA gene expression is stimulated by RUNX2 and SP7

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R-HSA-8939870
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Reaction [omitted]
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Homo sapiens
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While RUNX2 and SP7 (OSX), based on mouse studies, can stimulate the UCMA gene expression independently of each other, simultaneous binding of RUNX2 and SP7 to adjacent RUNX2 and SP7 binding sites, respectively, in the UCMA promoter, synergistically activates UCMA transcription. UCMA stimulates osteoblast differentiation and formation of mineralized nodules (Lee et al. 2015).

Literature References
PubMed ID Title Journal Year
25865393 Ucma, a direct transcriptional target of Runx2 and Osterix, promotes osteoblast differentiation and nodule formation

Lee, YJ, Park, SY, Lee, SJ, Boo, YC, Choi, JY, Kim, JE

Osteoarthr. Cartil. 2015
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