ITGBL1 gene expression is stimulated by RUNX2

Stable Identifier
R-HSA-8939829
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
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ITGBL1 gene expression is stimulated by RUNX2
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Binding of RUNX2, presumably associated with CBFB, to RUNX2 response elements in the promoter of the ITGBL1 gene stimulates ITGBL1 transcription. ITGBL1 encodes Integrin beta-like protein 1, which is implicated in regulation of TGF-beta signaling and RUNX2-induced bone metastasis of breast cancer (Li et al. 2015).

Literature References
PubMed ID Title Journal Year
26060017 ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGFβ Signaling Pathway

Li, XQ, Du, X, Li, DM, Kong, PZ, Sun, Y, Liu, PF, Wang, QS, Feng, YM

Cancer Res. 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX2:CBFB:ITGBL1 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX2:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-21)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-21)
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