26S proteasome degrades PolyUb-RUNX2

Stable Identifier
R-HSA-8939801
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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Polyubiquitinated RUNX2 is degraded by the proteasome. As it has not been examined whether SCF(SKP2)-mediated polyubiquitination of RUNX2 leads to translocation of PolyUb-RUNX2 to the cytosol (Thacker et al. 2016), proteasome mediated degradation is assumed to happen in the nucleus. This process is inhibited by glucose uptake in osteoblasts (Wei et al. 2015).

Literature References
PubMed ID Title Journal Year
26091038 Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation

Pessin, JE, Wei, J, Lezaki, T, Hinoi, E, Shimazu, J, Kajimura, D, Karsenty, G, Zong, H, Maurizi, A, Makinistoglu, MP, Takarada, T

Cell 2015
26778333 Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2

Khan, MP, Kumar, Y, Trivedi, AK, Kanaujiya, JK, Kapoor, I, Sanyal, S, Thacker, G, Chattopadhyay, N, Lochab, S, Ahmed, S, Shukla, N

Biochim. Biophys. Acta 2016
Participants
Participates
Catalyst Activity

endopeptidase activity of 26S proteasome [nucleoplasm]

Orthologous Events
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