ITGA5 gene expression is stimulated by RUNX2:CBFB

Stable Identifier
R-HSA-8939667
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ITGA5 gene expression is stimulated by RUNX2:CBFB
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of RUNX2, presumably associated with CBFB, to OSE2 (osteoblast specific element 2) sites in the promoter of the ITGA5 stimulates ITGA5 transcription. Integrin alpha-5, encoded by the ITGA5 gene, promotes adhesion of breast cancer cells to the bone, thus facilitating formation of bone metastases (Li et al. 2016).

Literature References
PubMed ID Title Journal Year
27317874 RUNX2 promotes breast cancer bone metastasis by increasing integrin α5-mediated colonization

Li, XQ, Lu, JT, Tan, CC, Wang, QS, Feng, YM

Cancer Lett. 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX2:CBFB:ITGA5 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX2:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-20)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-20)
Cite Us!