RUNX1 regulates transcription of genes involved in WNT signaling

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R-HSA-8939256
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Homo sapiens
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The RUNX1:CBFB complex directly regulates transcription of at least two components of WNT signaling. In association with its co-factor FOXP3, the RUNX1:CBFB complex stimulates transcription of the RSPO3 gene, encoding a WNT ligand that is implicated as a breast cancer oncogene (Recouvreux et al. 2016). In association with the activated estrogen receptor alpha (ESR1), the RUNX1:CBFB complex stimulates the expression of AXIN1, which functions as a regulator of WNT signaling (Stender et al. 2010).

Literature References
PubMed ID Title Journal Year
20547749 Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation

Kraus, WL, Stender, JD, Benner, C, Charn, TH, Kim, K, Chang, KC, Katzenellenbogen, BS, Glass, CK, Komm, B

Mol. Cell. Biol. 2010
26735887 RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes

Castilla, LH, Rubinstein, N, Grasso, EN, Echeverria, PC, Rocha-Viegas, L, Recouvreux, MS, Tocci, JM, Schere-Levy, C, Kordon, EC

Oncotarget 2016
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