Reactome | RUNX1 regulates transcription of genes involved in differentiation of myeloid cells

RUNX1 regulates transcription of genes involved in differentiation of myeloid cells

Stable Identifier

R-HSA-8939246

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

RUNX1 regulates transcription of genes involved in differentiation of myeloid cells

Click the image above or here to open this pathway in the Pathway Browser

The RUNX1:CBFB complex regulates expression of genes involved in differentiation of myeloid progenitors which can commit to hematopoietic lineages that lead to generation of platelets, erythrocytes, leukocytes or monocytes.
The RUNX1:CBFB complex recruits histone acetyltransferase CREBBP (CBP) to the promoter of the CSF2 gene, encoding Granulocyte-macrophage colony stimulating factor (GM-CSF), thus inducing GM-CSF expression (Oakford et al. 2010). GM-CSF induces growth, differentiation and survival of macrophages, granulocytes, erythrocytes and megakaryocytes from myeloid progenitors (Barreda et al. 2004).
The RUNX1:CBFB complex directly stimulates transcription of the LGALS3 gene, encoding galectin-3 (Zhang et al. 2009). Galectin-3 is expressed in myeloid progenitors and its levels increase during the maturation process (Le Marer 2000).
The PRKCB gene, encoding protein kinase C-beta, which regulates apoptosis of myeloid cells, is directly transactivated by the RUNX1:CBFB complex (Hu et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
14561740	A chromatin immunoprecipitation screen reveals protein kinase Cbeta as a direct RUNX1 target gene Hug, BA, Ahmed, N, Robbins, JA, Lazar, MA	J. Biol. Chem.	2004
10816326	GALECTIN-3 expression in differentiating human myeloid cells Le Marer, N	Cell Biol. Int.	2000
20439113	Transcriptional and epigenetic regulation of the GM-CSF promoter by RUNX1 Holloway, AF, Oakford, PC, West, AC, Qadi, A, James, SR, Cockerill, PN, Ray, SN, Bert, AG	Leuk. Res.	2010
19020999	RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors Coonse, K, Zhang, HY, Jin, L, Tanizaki, Y, Lloyd, RV, Raz, A, Ruebel, KH, Stilling, GA	Endocrine	2009
15062647	Regulation of myeloid development and function by colony stimulating factors Hanington, PC, Barreda, DR, Belosevic, M	Dev. Comp. Immunol.	2004