ESR-mediated signaling

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R-HSA-8939211
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Pathway
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Homo sapiens
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Estrogens are a class of hormones that play a role in physiological processes such as development, reproduction, metabolism of liver, fat and bone, and neuronal and cardiovascular function (reviewed in Arnal et al, 2017; Haldosen et al, 2014). Estrogens bind estrogen receptors, members of the nuclear receptor superfamily. Ligand-bound estrogen receptors act as nuclear transcription factors to regulate expression of genes that control cellular proliferation and differentiation, among other processes, but also play a non-genomic role in rapid signaling from the plasma membrane (reviewed in Hah et al, 2014;Schwartz et al, 2016).

Literature References
PubMed ID Title Journal Year
28539435 Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications

Katzenellenbogen, B, Chambon, P, Flouriot, G, Métivier, R, Henrion, D, Katzenellenbogen, J, Arnal, JF, Lenfant, F, Gourdy, P, Fontaine, C, Adlanmerini, M

Physiol. Rev. 2017
27288742 Rapid steroid hormone actions via membrane receptors

Verma, A, Schwartz, Z, Bivens, CB, Schwartz, N, Boyan, BD

Biochim. Biophys. Acta 2016
23954741 Estrogen receptor beta in breast cancer

Dahlman-Wright, K, Zhao, C, Haldosén, LA

Mol. Cell. Endocrinol. 2014
23810978 Hormone-regulated transcriptomes: lessons learned from estrogen signaling pathways in breast cancer cells

Kraus, WL, Hah, N

Mol. Cell. Endocrinol. 2014
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