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miR-215 Nonendonucleolytic Minimal RISC

Stable Identifier
R-HSA-8939112
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
Argonaute1/3/4: miR-215
Locations in the PathwayBrowser
Summation

The RNA-induced silencing complex contains an Argonaute (AGO) protein, whose PAZ domain binds the 3' end of the miRNA. The PIWI domain of AGO is responsible for cleavage of target RNAs, that is, RNAs complementary to the miRNA. Only AGO2 (EIF2C2) is capable of cleavage, however. AGO1 (EIF2C1), AGO3 (EIF2C3), and AGO4 (EIF2C4) repress translation of target RNAs by binding without cleavage.

Participants
Participant Of