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miR-215 Endonucleolytic Minimal RISC [cytosol]
Stable Identifier
R-HSA-8939108
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
Argonaute2: miR-215 (single-stranded)
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
Regulation of RUNX1 Expression and Activity (Homo sapiens)
RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 (Homo sapiens)
RUNX1 mRNA:miR-215 RISC [cytosol] (Homo sapiens)
miR-215 RISC [cytosol] (Homo sapiens)
miR-215 Endonucleolytic RISC [cytosol] (Homo sapiens)
miR-215 Endonucleolytic Minimal RISC [cytosol] (Homo sapiens)
miR-215 RISC [cytosol] (Homo sapiens)
miR-215 Endonucleolytic RISC [cytosol] (Homo sapiens)
miR-215 Endonucleolytic Minimal RISC [cytosol] (Homo sapiens)
miR-215 binds RUNX1 mRNA (Homo sapiens)
RUNX1 mRNA:miR-215 RISC [cytosol] (Homo sapiens)
miR-215 RISC [cytosol] (Homo sapiens)
miR-215 Endonucleolytic RISC [cytosol] (Homo sapiens)
miR-215 Endonucleolytic Minimal RISC [cytosol] (Homo sapiens)
miR-215 RISC [cytosol] (Homo sapiens)
miR-215 Endonucleolytic RISC [cytosol] (Homo sapiens)
miR-215 Endonucleolytic Minimal RISC [cytosol] (Homo sapiens)
General
The RNA-induced silencing complex contains an Argonaute (AGO) protein, whose PAZ domain binds the 3' end of the miRNA. The PIWI domain of AGO is responsible for cleavage of target RNAs, that is, RNAs complementary to the miRNA. Only AGO2 (EIF2C2) is capable of cleavage, however. AGO1 (EIF2C1), AGO3 (EIF2C3), and AGO4 (EIF2C4) repress translation of target RNAs by binding without cleavage.
Participants
components
AGO2 [cytosol]
(Homo sapiens)
miR-215 [cytosol]
(Homo sapiens)
Participates
as a component of
miR-215 Endonucleolytic RISC [cytosol] (Homo sapiens)
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