CR1 gene expression is stimulated by RUNX1

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Reaction [omitted]
Homo sapiens
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Binding of the RUNX1:CBFB complex to the promoter of the CR1 (CD35) gene stimulates CR1 transcription. The CR1 gene encodes Complement receptor type 1. Binding of an ETS family member to an ETS site adjacent to the RUNX1 site in the CR1 gene promoter probably contributes to CR1 expression (Kim et al. 1999, Rho et al. 2004).

Literature References
PubMed ID Title Journal Year
12220513 Correlation between cellular localization of TEL/AML1 fusion protein and repression of AML1-mediated transactivation of CR1 gene

Rho, JK, Kim, JH, Yu, J, Choe, SY

Biochem. Biophys. Res. Commun. 2002
10533284 AML1, the target of chromosomal rearrangements in human leukemia, regulates the expression of human complement receptor type 1 (CR1) gene

Kim, JH, Lee, S, Rho, JK, Choe, SY

Int. J. Biochem. Cell Biol. 1999
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