CR1 gene expression is stimulated by RUNX1

Stable Identifier
R-HSA-8939088
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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CR1 gene expression is stimulated by RUNX1
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Binding of the RUNX1:CBFB complex to the promoter of the CR1 (CD35) gene stimulates CR1 transcription. The CR1 gene encodes Complement receptor type 1. Binding of an ETS family member to an ETS site adjacent to the RUNX1 site in the CR1 gene promoter probably contributes to CR1 expression (Kim et al. 1999, Rho et al. 2004).

Literature References
PubMed ID Title Journal Year
10533284 AML1, the target of chromosomal rearrangements in human leukemia, regulates the expression of human complement receptor type 1 (CR1) gene

Choe, SY, Kim, JH, Rho, JK, Lee, S

Int. J. Biochem. Cell Biol. 1999
12220513 Correlation between cellular localization of TEL/AML1 fusion protein and repression of AML1-mediated transactivation of CR1 gene

Choe, SY, Rho, JK, Kim, JH, Yu, J

Biochem. Biophys. Res. Commun. 2002
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX1:CBFB:CR1 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-09-15)
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