PRKCB gene expression is stimulated by RUNX1

Stable Identifier
R-HSA-8939066
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PRKCB gene expression is stimulated by RUNX1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Binding of the RUNX1:CBFB complex to the promoter of the PRKCB gene, encoding Protein kinase C-beta, stimulates PRKCB transcription. RUNX1-mediated upregulation of PRKCB expression may contribute to apoptosis of myeloid cells (Hug et al. 2004).
Literature References
PubMed ID Title Journal Year
14561740 A chromatin immunoprecipitation screen reveals protein kinase Cbeta as a direct RUNX1 target gene

Hug, BA, Ahmed, N, Robbins, JA, Lazar, MA

J. Biol. Chem. 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX1:CBFB:PRKCB gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-09-15)
Cite Us!