Reactome | ENPP2 [plasma membrane]

ENPP2 [plasma membrane]

Stable Identifier

R-HSA-8938996

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ENPP2_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Metabolism of vitamins and cofactors (Homo sapiens)
  - Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
    - Vitamin B5 (pantothenate) metabolism (Homo sapiens)
      - ENPPs hydrolyse CoA-SH to PPANT, PAP (Homo sapiens)
        
        2xENPP1, 2xENPP2, 2xENPP3 [plasma membrane] (Homo sapiens)
        
        2xENPP2 [plasma membrane] (Homo sapiens)
        
        ENPP2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13822 ENPP2

Gene Names

ENPP2, ATX, PDNP2

Chain

signal peptide:1-27, propeptide:28-35, chain:36-863

Reference Genes

BioGPS Gene:5168 ENPP2

COSMIC (genes):ENPP2 ENPP2

CTD Gene:5168 ENPP2

dbSNP Gene:5168 ENPP2

ENSEMBL:ENSG00000136960 ENPP2

ENSEMBL_homo_sapiens_GENE:ENSG00000136960.13 ENPP2

HGNC:3357 ENPP2

KEGG Gene (Homo sapiens):5168 ENPP2

Monarch:5168 ENPP2

NCBI Gene:5168 ENPP2

OMIM:601060 ENPP2

UCSC:Q13822 ENPP2

Reference Transcript

Other Identifiers

11717672_s_at

11722777_a_at

11722778_s_at

11755337_a_at

17080516

209392_PM_at

209392_at

210839_PM_s_at

210839_s_at

3150580

3150581

3150587

3150588

3150589

3150590

3150593

3150597

3150601

3150605

3150607

3150608

3150610

3150611

3150614

3150616

3150618

3150619

3150623

3150624

3150627

3150631

3150633

3150634

3150637

3150639

3150640

3150641

3150643

3150644

3150645

41123_s_at

41124_r_at

5168

8152522

A_23_P94338

GE57737

GO:0002376

GO:0003676

GO:0003824

GO:0004528

GO:0004622

GO:0005044

GO:0005509

GO:0005576

GO:0005615

GO:0005886

GO:0006629

GO:0006644

GO:0006897

GO:0006935

GO:0006955

GO:0008270

GO:0009395

GO:0010634

GO:0016042

GO:0016192

GO:0016787

GO:0016788

GO:0030149

GO:0030247

GO:0030334

GO:0034638

GO:0036211

GO:0038024

GO:0046872

GO:0047391

GO:0048856

GO:0048870

GO:0050731

GO:0110165

GO:2000394

HMNXSV003008312

ILMN_1780799

ILMN_2373791

L35594_at

L46720_s_at

PH_hs_0022044

TC08001556.hg

g537905_3p_at

g662289_3p_a_at

Participates

as a component of

2xENPP2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001035181.1, NP_006200.3, NP_001124335.1

Guide to Pharmacology - Targets

2901

OpenTargets

ENSG00000136960

ZINC - Substances

ENPP2_HUMAN

ZINC - Biogenic

ENPP2_HUMAN

ZINC target

Q13822

PRO

Q13822

PDB

4ZG6, 4ZG7, 5MHP, 4ZG9, 5M7M, 5KXA, 4ZGA

ZINC - Metabolites

ENPP2_HUMAN

GeneCards

Q13822

HPA

ENSG00000136960-ENPP2

Ensembl

ENSP00000428291, ENST00000259486, ENSP00000259486, ENSP00000075322, ENSG00000136960, ENST00000522826, ENST00000075322

Pharos - Targets

Q13822

ZINC - Predictions - Purchasable

ENPP2_HUMAN

Orphanet

24511

HMDB Protein

HMDBP00167

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