Reactome | WDR33 [nucleoplasm]

WDR33 [nucleoplasm]

Stable Identifier

R-HSA-8938784

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

pre-mRNA 3' end processing protein WDR33, WDR33_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus-Host Interactions (Homo sapiens)
        
        NS5 interacts with Spliceosome (Homo sapiens)
        
        NS5:Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        WDR33 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        WDR33 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        WDR33 [nucleoplasm] (Homo sapiens)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        WDR33 [nucleoplasm] (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        WDR33 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9C0J8 WDR33

Gene Names

WDR33, WDC146

Chain

initiator methionine:1, chain:2-1336

Reference Genes

BioGPS Gene:55339 WDR33

COSMIC (genes):WDR33 WDR33

CTD Gene:55339 WDR33

dbSNP Gene:55339 WDR33

ENSEMBL:ENSG00000136709 WDR33

HGNC:25651 WDR33

KEGG:hsa:55339 WDR33

Monarch:55339 WDR33

NCBI Gene:55339 WDR33

OMIM:618082 WDR33

UCSC:Q9C0J8 WDR33

Reference Transcript

Participates

as an input of

Formation of the CPSF complex (Homo sapiens)

as a component of

Inferred To

pfs2 [nucleoplasm] (Schizosaccharomyces pombe)

WDR33 [nucleoplasm] (Bos taurus)

WDR33 [nucleoplasm] (Canis familiaris)

WDR33 [nucleoplasm] (Dictyostelium discoideum)

WDR33 [nucleoplasm] (Gallus gallus)

WDR33 [nucleoplasm] (Sus scrofa)

wdr33 [nucleoplasm] (Danio rerio)

wdr33 [nucleoplasm] (Xenopus tropicalis)

Wdr33 [nucleoplasm] (Drosophila melanogaster)

Wdr33 [nucleoplasm] (Mus musculus)

pfs-2 [nucleoplasm] (Caenorhabditis elegans)

PFS2 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of WDR33 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_011509738.1, NP_001006623.1, NP_001006624.1, XP_054198800.1, NP_060853.3

OpenTargets

ENSG00000136709

ENSEMBL

ENSG00000136709, ENSP00000376730, ENST00000322313, ENST00000409658, ENST00000393006, ENSP00000387186, ENSP00000325377

HPA

ENSG00000136709-WDR33

GeneCards

WDR33

PRO

Q9C0J8

Pharos - Targets

Q9C0J8

GlyGen

Q9C0J8

PDB

6F9N, 6URG, 8R8R, 6BLY, 6DNH, 6URO, 8E3Q, 6BM0, 8E3I, 6FUW

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.669	3
UniProt:Q9UKF6 CPSF3	2	Ub-K63-CPSF3 [nucleoplasm] (R-HSA-9970273) CPSF3 [nucleoplasm] (R-HSA-71993)	0.643	3
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.527	2
UniProt:O95639 CPSF4	1	CPSF4 [nucleoplasm] (R-HSA-169104)	0.527	5
UniProt:Q9BRK4 LZTS2			0.527	2
UniProt:Q6UN15 FIP1L1	9	FIP1L1 [nucleoplasm] (R-HSA-6805150) FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9672499) FIP1L1(1-272)-PDGFRA(567-1089) fusion [cytosol] (R-HSA-9672496) FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol] (R-HSA-9672502) FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol] (R-HSA-9672506) p-11Y-FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673872) p-11Y-FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol] (R-HSA-9673621) p-11Y-FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol] (R-HSA-9673879) p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol] (R-HSA-9673867)	0.527	2
UniProt:O15460 P4HA2	1	P4HA2 [endoplasmic reticulum lumen] (R-HSA-2980974)	0.527	3
UniProt:Q7Z4N8 P4HA3	1	P4HA3 [endoplasmic reticulum lumen] (R-HSA-2980915)	0.527	2
UniProt:P49760 CLK2			0.527	2
UniProt:Q9P2I0 CPSF2	1	CPSF2 [nucleoplasm] (R-HSA-71991)	0.527	2
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.527	2
UniProt:Q92797 SYMPK	1	SYMPK [nucleoplasm] (R-HSA-4615988)	0.527	2
UniProt:A6NMK7 CPS4L			0.527	2
UniProt:Q10570 CPSF1	1	CPSF1 [nucleoplasm] (R-HSA-71989)	0.499	3
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.483	2
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987) CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368)	0.483	2
UniProt:Q13595 TRA2A			0.483	2

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