RNF144A binds PRKDC and Ubiquitin:UBE2L3

Stable Identifier
R-HSA-8938770
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, endosome membrane
ReviewStatus
5/5
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RNF144A binds PRKDC and Ubiquitin:UBE2L3
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The ubiquitin E3 ligase RNF144A located on endosomal membranes (Ho et al. 2015) binds the catalytic subunit of DNA-dependent protein kinase (PRKDC, DNA-PKcs) and the E2-ubiquitin conjugate UBE2L3:Ubiquitin (UBCH7:Ubiquitin) located in the cytoplasm (Ho et al. 2014).
Literature References
PubMed ID Title Journal Year
24979766 RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage

Lin, WC, Mahanic, CS, Ho, SR, Lee, YJ

Proc. Natl. Acad. Sci. U.S.A. 2014
26216882 Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain

Lin, WC, Ho, SR, Lee, YJ

J. Biol. Chem. 2015
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Orthologous Events
RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Bos taurus)
RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Canis familiaris)
RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Dictyostelium discoideum)
RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Gallus gallus)
RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Mus musculus)
RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Rattus norvegicus)
RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Sus scrofa)
Authored
May, B  (2016-09-11)
Reviewed
Lin, WC  (2016-10-18)
Created
May, B  (2016-09-11)
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