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K48polyUb-PRKDC [cytosol]
Stable Identifier
R-HSA-8938766
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
DNA-dependent protein kinase catalytic subunit, PRKDC_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P46531 NOTCH1
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
RNF144A polyubiquitinates PRKDC (Homo sapiens)
K48polyUb-PRKDC [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78527 PRKDC
Gene Names
PRKDC, HYRC, HYRC1
Chain
chain:1-4128
Reference Genes
BioGPS Gene:5591 PRKDC
COSMIC (genes):PRKDC PRKDC
CTD Gene:5591 PRKDC
dbSNP Gene:5591 PRKDC
ENSEMBL:ENSG00000253729 PRKDC
ENSEMBL_homo_sapiens_GENE:ENSG00000253729.9 PRKDC
HGNC:9413 PRKDC
KEGG Gene (Homo sapiens):5591 PRKDC
Monarch:5591 PRKDC
NCBI Gene:5591 PRKDC
OMIM:600899 PRKDC
UCSC:P78527 PRKDC
Reference Transcript
RefSeq:NM_006904.6 PRKDC
RefSeq:NM_001081640.1 PRKDC
Other Identifiers
11719391_a_at
11740423_a_at
11749467_a_at
11757399_s_at
1250_at
17076867
2012_s_at
208694_PM_at
208694_at
210543_PM_s_at
210543_s_at
3134045
3134046
3134047
3134048
3134049
3134050
3134052
3134053
3134058
3134059
3134060
3134061
3134064
3134067
3134068
3134070
3134071
3134072
3134074
3134075
3134077
3134078
3134079
3134081
3134082
3134083
3134084
3134085
3134086
3134087
3134088
3134089
3134090
3134092
3134094
3134095
3134098
3134100
3134101
3134102
3134103
3134104
3134105
3134107
3134108
3134111
3134112
3134113
3134115
3134116
3134117
3134118
3134119
3134120
3134121
3134122
3134124
3134125
3134126
3134127
3134129
3134130
3134132
3134133
3134137
3134138
3134139
3134140
3134141
3134142
3134145
3134146
3134147
3134148
3134151
3134154
3134155
3134156
3134159
3134160
3134161
3134165
3134169
3134171
3134172
3134173
3134174
3134176
3134177
3134179
3134180
3134181
3134182
3134184
3134186
3134187
3134188
3134189
3134190
3134191
3134192
3134193
3134194
3134195
3134197
3134198
40129_at
5591
8150599
A_23_P9603
A_32_P25204
A_33_P3337599
GE62614
GE81694
GO:0000166
GO:0000278
GO:0000460
GO:0000723
GO:0000781
GO:0000785
GO:0001756
GO:0001933
GO:0002218
GO:0002326
GO:0002327
GO:0002328
GO:0002360
GO:0002376
GO:0003677
GO:0003690
GO:0003723
GO:0003824
GO:0004672
GO:0004674
GO:0004677
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005730
GO:0005829
GO:0005958
GO:0006281
GO:0006302
GO:0006303
GO:0006310
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006468
GO:0006974
GO:0007420
GO:0007507
GO:0008630
GO:0010212
GO:0010332
GO:0012501
GO:0016020
GO:0016233
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018107
GO:0019899
GO:0019904
GO:0022414
GO:0023052
GO:0030098
GO:0030154
GO:0031571
GO:0031648
GO:0032040
GO:0032200
GO:0032869
GO:0032991
GO:0032993
GO:0033077
GO:0033151
GO:0033152
GO:0033153
GO:0034462
GO:0034511
GO:0035234
GO:0035979
GO:0036211
GO:0042254
GO:0042752
GO:0043065
GO:0043066
GO:0043226
GO:0045087
GO:0045621
GO:0045648
GO:0045727
GO:0045944
GO:0048511
GO:0048584
GO:0048660
GO:0048856
GO:0050678
GO:0051171
GO:0060255
GO:0061629
GO:0065003
GO:0070418
GO:0070419
GO:0080090
GO:0080135
GO:0097681
GO:0098542
GO:0106310
GO:0140096
GO:0160049
GO:1902036
GO:1905221
GO:2001034
HMNXSV003015027
ILMN_1769517
ILMN_2253648
ILMN_2334121
PH_hs_0025022
RNA146935|p0039_imsncRNA85
TC08001191.hg
U35835_s_at
U47077_at
g13570016_3p_at
g13570016_3p_x_at
g13606055_3p_a_at
Participates
as an output of
RNF144A polyubiquitinates PRKDC (Homo sapiens)
Other forms of this molecule
PRKDC [cytosol]
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
PRKDC [nucleoplasm]
Inferred To
PRKDC [cytosol]
(Bos taurus)
PRKDC [cytosol]
(Canis familiaris)
PRKDC [cytosol]
(Sus scrofa)
K48polyUb-PRKDC [cytosol]
(Gallus gallus)
dnapkcs [cytosol]
(Dictyostelium discoideum)
Prkdc [cytosol]
(Mus musculus)
Prkdc [cytosol]
(Rattus norvegicus)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001075109.1
,
NP_008835.5
ZINC - World Drugs
PRKDC_HUMAN
Guide to Pharmacology - Targets
2800
OpenTargets
ENSG00000253729
ZINC - FDA approved
PRKDC_HUMAN
ZINC - Substances
PRKDC_HUMAN
ZINC target
P78527
ZINC - Biogenic
PRKDC_HUMAN
PRO
P78527
PDB
8EZ9
,
5W1R
,
7K1J
,
7TYR
,
7Z88
,
7LT3
,
7OTV
,
7OTW
,
6ZHA
,
5Y3R
,
7Z87
,
8BH3
,
7SUD
,
6ZH6
,
7K1B
,
7SGL
,
8BOT
,
7OTP
,
6ZH8
,
6ZFP
,
8BHY
,
7NFC
,
6ZH2
,
8BHV
,
7K19
,
7OTM
,
7NFE
,
6ZH4
,
5LUQ
,
7K1K
,
7K1N
,
6ZHE
,
7OTY
,
7K10
,
7K0Y
,
8EZB
,
8EZA
,
7SU3
,
7K11
ZINC - Investigational
PRKDC_HUMAN
GeneCards
P78527
HPA
ENSG00000253729-PRKDC
Ensembl
ENSP00000313420
,
ENSP00000345182
,
ENST00000338368
,
ENSG00000253729
,
ENST00000314191
Pharos - Targets
P78527
Orphanet
21609
ZINC - Predictions - Purchasable
PRKDC_HUMAN
HMDB Protein
HMDBP01324
Interactors (35)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13010 XRCC5
4
XRCC5 [extracellular region]
(R-HSA-6806530)
XRCC5 [secretory granule lumen]
(R-HSA-6801297)
XRCC5 [cytosol]
(R-HSA-3134849)
XRCC5 [nucleoplasm]
(R-HSA-58274)
0.901
9
UniProt:P12956 XRCC6
5
XRCC6 [secretory granule lumen]
(R-HSA-6801312)
XRCC6 [extracellular region]
(R-HSA-6806444)
XRCC6 [ficolin-1-rich granule lumen]
(R-HSA-6801300)
XRCC6 [cytosol]
(R-HSA-3134813)
XRCC6 [nucleoplasm]
(R-HSA-58272)
0.896
8
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.706
20
UniProt:Q96SD1 DCLRE1C
3
p-S516,S645-DCLRE1C [nucleoplasm]
(R-HSA-5687176)
p-S645-DCLRE1C [nucleoplasm]
(R-HSA-5686708)
DCLRE1C [nucleoplasm]
(R-HSA-5686712)
0.702
5
UniProt:P09874 PARP1
4
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.643
6
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.643
3
UniProt:P22415 USF1
2
USF1 [nucleoplasm]
(R-HSA-9023562)
pT153 USF1 [nucleoplasm]
(R-HSA-9855887)
0.623
5
UniProt:P21709 EPHA1
2
p-Y599,Y605-EPHA1 [plasma membrane]
(R-HSA-3928336)
EPHA1 [plasma membrane]
(R-HSA-211415)
0.615
3
UniProt:P11388 TOP2A
3
TOP2A [nucleoplasm]
(R-HSA-1362276)
polySUMO2,3-TOP2A [nucleoplasm]
(R-HSA-4641298)
monoSUMO1-K-TOP2A [nucleoplasm]
(R-HSA-4641367)
0.597
3
UniProt:Q9Y4R8 TELO2
0.597
5
UniProt:P11387 TOP1
2
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
TOP1 [nucleoplasm]
(R-HSA-4641363)
0.597
3
UniProt:Q96RI1-2 NR1H4
2
SUMO1-K132,K289-NR1H4 [nucleoplasm]
(R-HSA-4755487)
NR1H4-2 [nucleoplasm]
(R-HSA-3196161)
0.558
4
IntAct:EBI-2602074 TMPS2
0.527
4
IntAct:EBI-3954042 PLA1A
0.527
4
UniProt:Q13618 CUL3
3
G76-NEDD8-K712-CUL3 [cytosol]
(R-HSA-8952516)
CUL3 [nucleoplasm]
(R-HSA-5635033)
CUL3 [cytosol]
(R-HSA-975979)
0.527
2
UniProt:O43156 TTI1
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:O00743 PPP6C
2
PPP6C [cytosol]
(R-HSA-5685719)
PPP6C [nucleoplasm]
(R-HSA-9686576)
0.527
2
IntAct:EBI-1776214 KLK3
0.527
4
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P17947 SPI1
1
SPI1 [nucleoplasm]
(R-HSA-8865503)
0.525
2
UniProt:P50549 ETV1
0.525
2
UniProt:P14921 ETS1
2
ETS1 [nucleoplasm]
(R-HSA-1629809)
p-T38-ETS1 [nucleoplasm]
(R-HSA-3132720)
0.525
2
UniProt:O43918 AIRE
0.499
2
UniProt:P09629 HXB7
0.499
2
UniProt:Q9BPZ7 MAPKAP1
1
MAPKAP1 [cytosol]
(R-HSA-3006620)
0.499
2
UniProt:P10276 RARA
3
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
RARA [nucleoplasm]
(R-HSA-446164)
0.499
3
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.499
2
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.499
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.483
2
UniProt:P68431 HIST1H3G
20
2xAcK-HIST1H3A [nucleoplasm]
(R-HSA-427507)
Me1K5-H3C1 [nucleoplasm]
(R-HSA-9677683)
Ack-Me3K5-HIST1H3A [nucleoplasm]
(R-HSA-4551293)
AcK-Me3K10-HIST1H3A [nucleoplasm]
(R-HSA-4551291)
AcK-Me3K28-HIST1H3A [nucleoplasm]
(R-HSA-4551292)
Me2aR27-HIST1H3A [nucleoplasm]
(R-HSA-5229052)
Me2aR18-HIST1H3A [nucleoplasm]
(R-HSA-5229062)
Me2sR9-HIST1H3A [nucleoplasm]
(R-HSA-5211328)
Me2sR3-HIST1H3A [nucleoplasm]
(R-HSA-5218935)
AcK9,14-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8870893)
AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871271)
AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871306)
AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871294)
AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8865596)
AcK14,18-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871295)
AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871288)
AcK14,18-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871299)
AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871286)
Me2K28-HIST1H3A [nucleoplasm]
(R-HSA-4754193)
MeK37-HIST1H3A [nucleoplasm]
(R-HSA-4722135)
0.483
2
UniProt:P46531 NOTCH1
20
NOTCH1 L1678P S2 cleavage fragment [extracellular region]
(R-HSA-2730745)
NOTCH1 I1680N S2 cleavage fragment [extracellular region]
(R-HSA-2730744)
NOTCH1 I1718T S2 cleavage fragment [extracellular region]
(R-HSA-2730757)
NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
(R-HSA-2730742)
NOTCH1 V1676D S2 cleavage fragment [extracellular region]
(R-HSA-2730755)
NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
(R-HSA-2684869)
NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
(R-HSA-2684881)
NOTCH1 I1616T Extracellular Fragment [extracellular region]
(R-HSA-2684866)
NOTCH1 L1596H Extracellular Fragment [extracellular region]
(R-HSA-2684853)
NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
(R-HSA-1485591)
NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
(R-HSA-1485585)
NOTCH1 I1616N Extracellular Fragment [extracellular region]
(R-HSA-2684862)
NOTCH1 L1593P Extracellular Fragment [extracellular region]
(R-HSA-1485584)
NOTCH1 R1598P Extracellular Fragment [extracellular region]
(R-HSA-1485592)
NOTCH1 V1576E Extracellular Fragment [extracellular region]
(R-HSA-2684852)
NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
(R-HSA-2684874)
NOTCH1 F1592S Extracellular Fragment [extracellular region]
(R-HSA-2684847)
NOTCH1 L1574Q Extracellular Fragment [extracellular region]
(R-HSA-2691203)
p-NICD1 Q2440* [nucleoplasm]
(R-HSA-2902207)
p-NICD1 Q2395* [nucleoplasm]
(R-HSA-2902205)
0.462
2
UniProt:P11308 ERG
0.462
7
UniProt:P51858 HDGF
1
HDGF [nucleoplasm]
(R-HSA-535593)
0.462
3
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.462
2
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