LGALS3 gene expression is stimulated by RUNX1 and RUNX2

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Reaction [omitted]
Homo sapiens
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Binding of the RUNX1:CBFB or RUNX2:CBFB complex to RUNX response elements in the promoter of the LGALS3 gene stimulates LGLAS3 transcription. The LGALS3 gene encodes Galectin-3, which is highly expressed in pituitary tumors and glioma (Vladimirova et al. 2008, Zhang et al. 2009). Galectin-3 is expressed in myeloid progenitors and its levels increase during the maturation process (Le Marer 2000).

Literature References
PubMed ID Title Journal Year
19020999 RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors

Zhang, HY, Jin, L, Stilling, GA, Ruebel, KH, Coonse, K, Tanizaki, Y, Raz, A, Lloyd, RV

Endocrine 2009
18438928 Runx2 is expressed in human glioma cells and mediates the expression of galectin-3

Vladimirova, V, Waha, A, L├╝ckerath, K, Pesheva, P, Probstmeier, R

J. Neurosci. Res. 2008
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