LGALS3 gene expression is stimulated by RUNX1 and RUNX2

Stable Identifier
R-HSA-8938382
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
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LGALS3 gene expression is stimulated by RUNX1 and RUNX2
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Binding of the RUNX1:CBFB or RUNX2:CBFB complex to RUNX response elements in the promoter of the LGALS3 gene stimulates LGLAS3 transcription. The LGALS3 gene encodes Galectin-3, which is highly expressed in pituitary tumors and glioma (Vladimirova et al. 2008, Zhang et al. 2009). Galectin-3 is expressed in myeloid progenitors and its levels increase during the maturation process (Le Marer 2000).

Literature References
PubMed ID Title Journal Year
18438928 Runx2 is expressed in human glioma cells and mediates the expression of galectin-3

Pesheva, P, Vladimirova, V, Lückerath, K, Probstmeier, R, Waha, A

J. Neurosci. Res. 2008
19020999 RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors

Coonse, K, Zhang, HY, Jin, L, Tanizaki, Y, Lloyd, RV, Raz, A, Ruebel, KH, Stilling, GA

Endocrine 2009
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX2:CBFB:LGALS3 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX2:CBFB [nucleoplasm]
Regulator
RUNX1:CBFB:LGALS3 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Ducy, P  (2017-08-04)
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-09-09)
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