Binding of the RUNX1:CBFB or RUNX2:CBFB complex to RUNX response elements in the promoter of the LGALS3 gene stimulates LGLAS3 transcription. The LGALS3 gene encodes Galectin-3, which is highly expressed in pituitary tumors and glioma (Vladimirova et al. 2008, Zhang et al. 2009). Galectin-3 is expressed in myeloid progenitors and its levels increase during the maturation process (Le Marer 2000).