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RMB14 binds RUNX2
Stable Identifier
R-HSA-8938356
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
RUNX2 regulates bone development (Homo sapiens)
RMB14 binds RUNX2 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RBM14 (CoAA) binds RUNX2. This interaction involves the C-terminus of RBM14 and the Runt domain of RUNX2. It has not been examined whether RBM14 interacts with RUNX2 alone or in the context of the RUNX2:CBFB complex. Formation of the RUNX2:RBM14 complex prevents binding of RUNX2 to its target promoters and thus interferes with activation of RUNX2 target genes. RBM14 is frequently overexpressed in osteosarcoma (Li et al. 2009).
Literature References
PubMed ID
Title
Journal
Year
19585539
Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors
Gopalakrishnan, R
,
Jensen, ED
,
Westendorf, JJ
,
Li, X
,
Hoeppner, LH
J. Cell. Biochem.
2009
Participants
Input
RBM14 [nucleoplasm]
(Homo sapiens)
RUNX2 [nucleoplasm]
(Homo sapiens)
Output
RUNX2:RBM14 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
RUNX2 regulates bone development (Homo sapiens)
Orthologous Events
RMB14 binds RUNX2 (Bos taurus)
RMB14 binds RUNX2 (Caenorhabditis elegans)
RMB14 binds RUNX2 (Canis familiaris)
RMB14 binds RUNX2 (Danio rerio)
RMB14 binds RUNX2 (Drosophila melanogaster)
RMB14 binds RUNX2 (Gallus gallus)
RMB14 binds RUNX2 (Mus musculus)
RMB14 binds RUNX2 (Sus scrofa)
Authored
Orlic-Milacic, M (2016-09-09)
Reviewed
Ducy, P (2017-08-04)
Created
Orlic-Milacic, M (2016-09-09)
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