RMB14 binds RUNX2

Stable Identifier
R-HSA-8938356
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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RMB14 binds RUNX2
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RBM14 (CoAA) binds RUNX2. This interaction involves the C-terminus of RBM14 and the Runt domain of RUNX2. It has not been examined whether RBM14 interacts with RUNX2 alone or in the context of the RUNX2:CBFB complex. Formation of the RUNX2:RBM14 complex prevents binding of RUNX2 to its target promoters and thus interferes with activation of RUNX2 target genes. RBM14 is frequently overexpressed in osteosarcoma (Li et al. 2009).

Literature References
PubMed ID Title Journal Year
19585539 Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors

Li, X, Hoeppner, LH, Jensen, ED, Gopalakrishnan, R, Westendorf, JJ

J. Cell. Biochem. 2009
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Orthologous Events
RMB14 binds RUNX2 (Caenorhabditis elegans)
RMB14 binds RUNX2 (Canis familiaris)
RMB14 binds RUNX2 (Danio rerio)
RMB14 binds RUNX2 (Drosophila melanogaster)
RMB14 binds RUNX2 (Gallus gallus)
RMB14 binds RUNX2 (Mus musculus)
RMB14 binds RUNX2 (Rattus norvegicus)
RMB14 binds RUNX2 (Sus scrofa)
RMB14 binds RUNX2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-09-09)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-09)