RBM14 (CoAA) binds RUNX2. This interaction involves the C-terminus of RBM14 and the Runt domain of RUNX2. It has not been examined whether RBM14 interacts with RUNX2 alone or in the context of the RUNX2:CBFB complex. Formation of the RUNX2:RBM14 complex prevents binding of RUNX2 to its target promoters and thus interferes with activation of RUNX2 target genes. RBM14 is frequently overexpressed in osteosarcoma (Li et al. 2009).
Li, X, Hoeppner, LH, Jensen, ED, Gopalakrishnan, R, Westendorf, JJ
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