RMB14 binds RUNX2

Stable Identifier
R-HSA-8938356
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RBM14 (CoAA) binds RUNX2. This interaction involves the C-terminus of RBM14 and the Runt domain of RUNX2. It has not been examined whether RBM14 interacts with RUNX2 alone or in the context of the RUNX2:CBFB complex. Formation of the RUNX2:RBM14 complex prevents binding of RUNX2 to its target promoters and thus interferes with activation of RUNX2 target genes. RBM14 is frequently overexpressed in osteosarcoma (Li et al. 2009).
Literature References
PubMed ID Title Journal Year
19585539 Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors

Gopalakrishnan, R, Jensen, ED, Westendorf, JJ, Li, X, Hoeppner, LH

J. Cell. Biochem. 2009
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!