NFE2 gene expression is stimulated by RUNX1:CBFB

Stable Identifier
R-HSA-8938338
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
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NFE2 gene expression is stimulated by RUNX1:CBFB
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Binding of the RUNX1:CBFB complex to the promoter of the NFE2 gene stimulates NFE2 transcription. The NFE2 gene encodes the Transcription factor NF-E2 45 kDa subunit. The NF-E2 transcription factor regulates erythroid and megakaryocytic maturation and differentiation and is overexpressed in myeloproliferative neoplasms (Wang et al. 2010).

Literature References
PubMed ID Title Journal Year
20339092 AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2

Hexner, EO, Schwemmers, S, Pahl, HL, Wang, W

Blood 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX1:CBFB:NFE2 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-09-09)
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