ENPPs hydrolyse CoA-SH to PPANT, PAP

Stable Identifier
R-HSA-8938314
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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ENPPs hydrolyse CoA-SH to PPANT, PAP
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Coenzyme A (CoA-SH) in serum can be hydrolysed by ectonucleotide pyrophosphatases (ENPPs) (Goding et al. 2003), which have pantothenate kinase activity. The products of this are adenosine 3',5'-bismonophosphate (PAP) and 4′-phosphopantetheine (PPANT), which is able to translocate into cells providing an alternative source for intracellular coenzyme A biosynthesis (Srinivasan et al. 2015).
Literature References
PubMed ID Title Journal Year
12757929 Physiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase/phosphodiesterase family

Goding, JW, Slegers, H, Grobben, B

Biochim. Biophys. Acta 2003
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Catalyst Activity

hydrolase activity of 2xENPP1, 2xENPP2, 2xENPP3 [plasma membrane]

Physical Entity
2xENPP1, 2xENPP2, 2xENPP3 [plasma membrane] (Homo sapiens)
Activity
hydrolase activity (GO:0016787)
Authored
Jupe, S  (2016-09-09)
Reviewed
D'Eustachio, P  (2016-10-28)
Created
Jupe, S  (2016-09-09)
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