ENPPs hydrolyse CoA-SH to PPANT, PAP

Stable Identifier
R-HSA-8938314
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Coenzyme A (CoA-SH) in serum can be hydrolysed by ectonucleotide pyrophosphatases (ENPPs) (Goding et al. 2003), which have pantothenate kinase activity. The products of this are adenosine 3',5'-bismonophosphate (PAP) and 4′-phosphopantetheine (PPANT), which is able to translocate into cells providing an alternative source for intracellular coenzyme A biosynthesis (Srinivasan et al. 2015).

Literature References
PubMed ID Title Journal Year
12757929 Physiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase/phosphodiesterase family

Goding, JW, Grobben, B, Slegers, H

Biochim. Biophys. Acta 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hydrolase activity of 2xENPP1, 2xENPP2, 2xENPP3 [plasma membrane]
Physical Entity
Activity
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