Vanin hydrolyses pantetheine to PanK, 2AET

Stable Identifier
Reaction [transition]
Homo sapiens
(R)-pantetheine + H2O => (R)-pantothenate + cysteamine
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Vanin (VNN1) is a membrane pantetheine hydrolase or pantetheinase (EC 3.56.1.-) (Maras et al. 1999, Martin et al. 2001), part of a cluster of three human orthologous genes (VNN1, VNN2, VNN3) on Chr. 6q22-24 (Kaskow et al. 2012, Boersma et al. 2014). VNN3 is a pseudogene in humans. Vanins catalyse the hydrolysis of pantetheine to pantothenic acid (PanK, vitamin B5) and cysteamine (2AET), a powerful anti-oxidant. PanK is the initial substrate for the synthesis of Coenzyme A (CoA-SH).

Mouse Vnn1 has been shown to be GPI-anchored to the outer face of the plasma membrane. Sequence motifs conserved with human VNN1 and VNN2 supports the inference that the human proteins are similarly anchored (Aurand-Lions et al. 1996; Naquet et al. 2020), so the enzymes are annotated as acting on extracellular panthetheine to generate extracellular PanK and 2AET.

Literature References
PubMed ID Title Journal Year
32234503 Regulation of coenzyme A levels by degradation: the 'Ins and Outs'

Kerr, EW, Leonardi, R, Naquet, P, Vickers, SD

Prog Lipid Res 2020
10567687 Is pantetheinase the actual identity of mouse and human vanin-1 proteins?

Pitari, G, Duprè, S, Barra, D, Maras, B

FEBS Lett. 1999
8934567 Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing

Imhof, BA, Aurrand-Lions, M, Zakharyev, VM, Bazin, H, Galland, F, Naquet, P

Immunity 1996
Catalyst Activity

pantetheine hydrolase activity of VNN1,VNN2 [plasma membrane]

Orthologous Events
Cross References
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