Vanin hydrolyses pantetheine to PanK, 2AET

Stable Identifier
R-HSA-8938300
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Vanin (VNN1) is a membrane pantetheine hydrolase or pantetheinase (EC 3.56.1.-) (Maras et al. 1999, Martin et al. 2001), part of a cluster of three human orthologous genes (VNN1, VNN2, VNN3) on Chr. 6q22-24 (Kaskow et al. 2012, Boersma et al. 2014). VNN3 is a pseudogene in humans. Vanins catalyse the hydrolysis of pantetheine to pantothenic acid (PanK, vitamin B5) and cysteamine (2AET), a powerful anti-oxidant. PanK is the initial substrate for the synthesis of Coenzyme A (CoA-SH).

Literature References
PubMed ID Title Journal Year
10567687 Is pantetheinase the actual identity of mouse and human vanin-1 proteins?

Maras, B, Barra, D, Duprè, S, Pitari, G

FEBS Lett. 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
pantetheine hydrolase activity of VNN1,VNN2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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