Reactome | Vanin hydrolyses pantetheine to PanK, 2AET

Vanin hydrolyses pantetheine to PanK, 2AET

Stable Identifier

R-HSA-8938300

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Synonyms

(R)-pantetheine + H2O => (R)-pantothenate + cysteamine

ReviewStatus

5/5

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Vanin hydrolyses pantetheine to PanK, 2AET

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Vanin (VNN1) is a membrane pantetheine hydrolase or pantetheinase (EC 3.56.1.-) (Maras et al. 1999, Martin et al. 2001), part of a cluster of three human orthologous genes (VNN1, VNN2, VNN3) on Chr. 6q22-24 (Kaskow et al. 2012, Boersma et al. 2014). VNN3 is a pseudogene in humans. Vanins catalyse the hydrolysis of pantetheine to pantothenic acid (PanK, vitamin B5) and cysteamine (2AET), a powerful anti-oxidant. PanK is the initial substrate for the synthesis of Coenzyme A (CoA-SH).

Mouse Vnn1 has been shown to be GPI-anchored to the outer face of the plasma membrane. Sequence motifs conserved with human VNN1 and VNN2 supports the inference that the human proteins are similarly anchored (Aurand-Lions et al. 1996; Naquet et al. 2020), so the enzymes are annotated as acting on extracellular panthetheine to generate extracellular PanK and 2AET.

Literature References

PubMed ID	Title	Journal	Year
32234503	Regulation of coenzyme A levels by degradation: the 'Ins and Outs' Naquet, P, Kerr, EW, Vickers, SD, Leonardi, R	Prog Lipid Res	2020
10567687	Is pantetheinase the actual identity of mouse and human vanin-1 proteins? Maras, B, Barra, D, Duprè, S, Pitari, G	FEBS Lett.	1999
8934567	Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing Aurrand-Lions, M, Galland, F, Bazin, H, Zakharyev, VM, Imhof, BA, Naquet, P	Immunity	1996