CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP

Stable Identifier
R-HSA-8938251
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
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Summation

Binding of the RUNX1:CBFB complex associated with the histone acetyltransferase (HAT) CREBBP (CBP) to the promoter of the CSF2 gene, encoding Granulocyte-macrophage colony stimulating factor (GM-CSF), stimulates CSF2 transcription. HAT activity of CREBBP is required for RUNX1-mediated stimulation of CSF2 expression. GM-CSF is involved in myeloid cell differentiation (Oakford et al. 2010). It has not been fully elucidated how recruitment of the SWI/SNF complex to the CSF2 promoter by RUNX1 affects CSF2 transcription (Bakshi et al. 2010).

Literature References
PubMed ID Title Journal Year
20439113 Transcriptional and epigenetic regulation of the GM-CSF promoter by RUNX1

Oakford, PC, James, SR, Qadi, A, West, AC, Ray, SN, Bert, AG, Cockerill, PN, Holloway, AF

Leuk. Res. 2010
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