Reactome | RUNX1 binds the SWI/SNF complex

RUNX1 binds the SWI/SNF complex

Stable Identifier

R-HSA-8938217

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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The RUNX1:CBFB complex can bind the SWI/SNF chromatin remodeling complex by directly interacting with at least three subunits of the SWI/SNF: BRG1 (SMARCA4), BAF155 (SMARCC1) and INI1 (SMARCB1). RUNX1 recruits the SWI/SNF complex to many of its target promoters, which is associated with changes in histone modifications at these promoters, but precise changes and their effect on gene expression have not been fully elucidated (Bakshi et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20506188	The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes Bakshi, R, Hassan, MQ, Pratap, J, Lian, JB, Montecino, MA, van Wijnen, AJ, Stein, JL, Imbalzano, AN, Stein, GS	J. Cell. Physiol.	2010