The RUNX1:CBFB complex can bind the SWI/SNF chromatin remodeling complex by directly interacting with at least three subunits of the SWI/SNF: BRG1 (SMARCA4), BAF155 (SMARCC1) and INI1 (SMARCB1). RUNX1 recruits the SWI/SNF complex to many of its target promoters, which is associated with changes in histone modifications at these promoters, but precise changes and their effect on gene expression have not been fully elucidated (Bakshi et al. 2010).
Bakshi, R, Hassan, MQ, Pratap, J, Lian, JB, Montecino, MA, van Wijnen, AJ, Stein, JL, Imbalzano, AN, Stein, GS
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