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MYL9 gene transcription is stimulated by RUNX1:CBFB
Stable Identifier
R-HSA-8938201
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
MYL9 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)
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Binding of the RUNX1:CBFB complex to the promoter of the MYL9 gene stimulates MYL9 transcription. All four RUNX1 response elements in the MYL9 promoter contribute to transactivation of the MYL9 gene. The MYL9 gene encodes Myosin regulatory light polypeptide, which functions as a regulatory subunit of the myosin complex. Myosin plays an important role in platelet activation and thrombopoiesis. RUNX1 haploinsuficiency is associated with decreased MYL9 expression and myosin light chain phosphorylation, which likely contributes to thrombocytopenia and platelet dysfunction (Jalagadugula et al. 2010).
Literature References
PubMed ID
Title
Journal
Year
20876458
Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency
Kaur, G
,
Dhanasekaran, DN
,
Rao, AK
,
Goldfinger, LE
,
Mao, G
,
Jalagadugula, G
Blood
2010
Participants
Input
MYL9 gene [nucleoplasm]
(Homo sapiens)
Output
MYL9 [cytosol]
(Homo sapiens)
Participates
as an event of
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
This event is regulated
Positively by
Regulator
RUNX1:CBFB:MYL9 gene [nucleoplasm]
(Homo sapiens)
Active Unit
RUNX1:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M (2016-09-14)
Reviewed
Chuang, LS (2016-12-20)
Ito, Y (2016-12-20)
Created
Orlic-Milacic, M (2016-09-08)
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