PRKCQ gene expression is stimulated by RUNX1:CBFB

Stable Identifier
R-HSA-8938158
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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PRKCQ gene expression is stimulated by RUNX1:CBFB
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Binding of the RUNX1:CBFB complex to the promoter of the PRKCQ gene, encoding Protein kinase C theta type, stimulates PRKCQ transcription. RUNX1 mutants associated with inherited thrombocytopenia are unable to transactivate the PRKCQ gene. PRKCQ is important for the functioning of megakaryocytes and platelets, but is not megakaryocyte specific (Jalagadugula et al. 2011).
Literature References
PubMed ID Title Journal Year
21252065 Platelet protein kinase C-theta deficiency with human RUNX1 mutation: PRKCQ is a transcriptional target of RUNX1

Kaur, G, Dhanasekaran, DN, Rao, AK, Mao, G, Jalagadugula, G

Arterioscler. Thromb. Vasc. Biol. 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX1:CBFB:PRKCQ gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-09-08)
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