PRKCQ gene expression is stimulated by RUNX1:CBFB

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R-HSA-8938158
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Reaction [omitted]
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Homo sapiens
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Binding of the RUNX1:CBFB complex to the promoter of the PRKCQ gene, encoding Protein kinase C theta type, stimulates PRKCQ transcription. RUNX1 mutants associated with inherited thrombocytopenia are unable to transactivate the PRKCQ gene. PRKCQ is important for the functioning of megakaryocytes and platelets, but is not megakaryocyte specific (Jalagadugula et al. 2011).

Literature References
PubMed ID Title Journal Year
21252065 Platelet protein kinase C-theta deficiency with human RUNX1 mutation: PRKCQ is a transcriptional target of RUNX1

Jalagadugula, G, Mao, G, Kaur, G, Dhanasekaran, DN, Rao, AK

Arterioscler. Thromb. Vasc. Biol. 2011
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