SERPINB13 binds cathepsin L

Stable Identifier
Reaction [binding]
Homo sapiens
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SERPINB13 binds the lysosomal cystein protease cathepsin L and inhibits its catalytic activity (Jayakumar et al. 2003, Welss et al. 2003). It is uncertain whether SERPINB13 functions in the lysosomes or exclusively in the cytosol, where it would inhibit the enzymatic activity of ectopic cathepsin L (Welss et al. 2003).

Literature References
PubMed ID Title Journal Year
12809493 Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis

Ruzicka, T, von Mikecz, A, Abts, HF, Irving, JA, Smith, AI, Blum, R, Sun, J, Whisstock, JC, Pike, RN, Welss, T, Bird, PI

Biochemistry 2003
12504904 Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis

Brömme, D, Silverman, GA, Jayakumar, A, Clayman, GL, Kang, Y, Pak, SC, Henderson, Y, Holton, PR, EL-Naggar, AK, Mitsudo, K, Frederick, MJ

Arch. Biochem. Biophys. 2003
Orthologous Events
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