Reactome | AUTS2 [nucleoplasm]

AUTS2 [nucleoplasm]

Stable Identifier

R-HSA-8937967

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Autism susceptibility gene 2 protein, AUTS2_HUMAN, KIAA0442

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds PRC1 complexes (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.5 [nucleoplasm] (Homo sapiens)
        
        AUTS2 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.5 [nucleoplasm] (Homo sapiens)
        
        AUTS2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WXX7 AUTS2

Gene Names

AUTS2, KIAA0442

Chain

chain:1-1259

Reference Genes

BioGPS Gene:26053 AUTS2

COSMIC (genes):AUTS2 AUTS2

CTD Gene:26053 AUTS2

dbSNP Gene:26053 AUTS2

ENSEMBL:ENSG00000158321 AUTS2

HGNC:14262 AUTS2

KEGG Gene (Homo sapiens):26053 AUTS2

Monarch:26053 AUTS2

NCBI Gene:26053 AUTS2

OMIM:607270 AUTS2

UCSC:Q8WXX7 AUTS2

Reference Transcript

Other Identifiers

0003940053

11737962_a_at

11738262_a_at

11738263_s_at

11743302_a_at

17046781

212599_at

243364_at

243365_s_at

26053

3006575

3006576

3006577

3006578

3006627

3006666

3006668

3006703

3006704

3006705

3006706

3006707

3006708

3006709

3006736

3006835

3006866

3006867

3006871

3006873

3006874

3006875

3006876

3006879

3006880

3006882

3006885

3006889

3006895

3006899

3006903

3006905

3006909

3006910

3006911

3006912

3006913

3006914

3006915

3006916

3006917

3006918

35648_at

42623_at

8133233

82629_at

82630_g_at

A_23_P122906

A_32_P809435

A_33_P3330209

A_33_P3330211

GE53189

GE650987

GO:0000902

GO:0001764

GO:0003674

GO:0003682

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005856

GO:0006464

GO:0007010

GO:0007165

GO:0008150

GO:0009058

GO:0010592

GO:0015629

GO:0022607

GO:0030154

GO:0030426

GO:0031532

GO:0034641

GO:0035022

GO:0040007

GO:0040011

GO:0042995

GO:0043226

GO:0045944

GO:0048675

GO:0048856

GO:0048870

GO:0051276

GO:0051571

GO:0097484

GO:2000620

Hs.167236.0.A1_3p_at

Hs.32168.0.S1_3p_at

ILMN_1749081

PH_hs_0023568

Participant Of

hasComponent

PRC1.5 [nucleoplasm]

Inferred To

LOC100362819 [nucleoplasm] (Rattus norvegicus)

auts2a [nucleoplasm] (Danio rerio)

AUTS2 [nucleoplasm] (Bos taurus)

AUTS2 [nucleoplasm] (Canis familiaris)

AUTS2 [nucleoplasm] (Sus scrofa)

auts2 [nucleoplasm] (Xenopus tropicalis)

Auts2 [nucleoplasm] (Mus musculus)

Cross References

RefSeq

NP_056385.1, NP_001120703.1, NP_001120704.1

OpenTargets

ENSG00000158321

GeneCards

Q8WXX7

HPA

ENSG00000158321-AUTS2

Ensembl

ENSP00000385572, ENSP00000385263, ENSG00000158321, ENST00000406775, ENST00000403018, ENST00000342771, ENSP00000344087

PRO

Q8WXX7

Orphanet

17272

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.643	3
UniProt:Q09472 EP300	5	Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) SUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.499	3