RUNX2:CBFB:p-Y-YAP1 binds the BGLAP gene promoter

Stable Identifier
R-HSA-8937869
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX2:CBFB:p-Y-YAP1 binds the BGLAP gene promoter
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Based on studies in rat, the complex of RUNX2, presumably associated with CBFB, and tyrosine phosphorylated YAP1 binds to the promoter of the BGLAP (osteocalcin) gene (Zaidi et al. 2004). RUNX2 binding sites are conserved in the human BGLAP gene promoter.

Literature References
PubMed ID Title Journal Year
14765127 Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

van Wijnen, AJ, Ito, Y, Medina, R, Lian, JB, Stein, JL, Stein, GS, Sullivan, AJ, Zaidi, SK

EMBO J. 2004
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Inferred From
Runx2:Cbfb:p-Y-Yap1 binds the Bglap gene promoter (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2016-09-07)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-07)
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