p-Y-YAP1 translocates to the nucleus

Stable Identifier
R-HSA-8937856
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
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p-Y-YAP1 translocates to the nucleus
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Based on studies in rat, YAP1, phosphorylated on an unknown tyrosine residue by SRC and/or YES1, translocates to the nucleus. Tyrosine phosphorylated YAP1 shuffles between the nucleus and the cytosol, and phosphorylation by SRC and/or YES1 does not change the ratio of nuclear and cytosolic YAP1 (Zaidi et al. 2004).

Literature References
PubMed ID Title Journal Year
14765127 Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

Zaidi, SK, Sullivan, AJ, Medina, R, Ito, Y, van Wijnen, AJ, Stein, JL, Lian, JB, Stein, GS

EMBO J. 2004
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Inferred From
p-Y-Yap1 translocates to the nucleus (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2016-09-07)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-07)