Reactome | SRC,YES1 bind YAP1

SRC,YES1 bind YAP1

Stable Identifier

R-HSA-8937820

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - RUNX2 regulates bone development (Homo sapiens)
        
        RUNX2 regulates osteoblast differentiation (Homo sapiens)
        
        SRC,YES1 bind YAP1 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Based on studies in rat osteosarcoma cell line, activated SRC and YES1 form a complex with YAP1 (Zaidi et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
14765127	Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription Zaidi, SK, Sullivan, AJ, Medina, R, Ito, Y, van Wijnen, AJ, Stein, JL, Lian, JB, Stein, GS	EMBO J.	2004