Reactome | SRC,YES1 bind YAP1

SRC,YES1 bind YAP1

Stable Identifier

R-HSA-8937820

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - RUNX2 regulates bone development (Homo sapiens)
        
        RUNX2 regulates osteoblast differentiation (Homo sapiens)
        
        SRC,YES1 bind YAP1 (Homo sapiens)

General

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Based on studies in rat osteosarcoma cell line, activated SRC and YES1 form a complex with YAP1 (Zaidi et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
14765127	Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription van Wijnen, AJ, Ito, Y, Medina, R, Lian, JB, Stein, JL, Stein, GS, Sullivan, AJ, Zaidi, SK	EMBO J.	2004