Reactome | AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates

AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates

Stable Identifier

R-HSA-8937191

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After ligand binding and activation, the AHR complex translocates to the nucleus where it disassociates from the chaperone subunits to then dimerise with the aryl hydrocarbon receptor nuclear translocator (ARNT) (Lees & Whitelaw 1999).

Literature References

PubMed ID	Title	Journal	Year
10409767	Multiple roles of ligand in transforming the dioxin receptor to an active basic helix-loop-helix/PAS transcription factor complex with the nuclear protein Arnt Lees, MJ, Whitelaw, ML	Mol. Cell. Biol.	1999