Reactome | AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates

AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates

Stable Identifier

R-HSA-8937191

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates

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After ligand binding and activation, the AHR complex translocates to the nucleus where it disassociates from the chaperone subunits to then dimerise with the aryl hydrocarbon receptor nuclear translocator (ARNT) (Lees & Whitelaw 1999).

Literature References

PubMed ID	Title	Journal	Year
10409767	Multiple roles of ligand in transforming the dioxin receptor to an active basic helix-loop-helix/PAS transcription factor complex with the nuclear protein Arnt Lees, MJ, Whitelaw, ML	Mol. Cell. Biol.	1999

Participants

Input

AHR:TCDD:2xHSP90AB1:AIP:PTGES3 [nucleoplasm] (Homo sapiens)

Output

Participates

as an event of

Aryl hydrocarbon receptor signalling (Homo sapiens)

Catalyst Activity

nuclear receptor activity of AHR:TCDD:2xHSP90AB1:AIP:PTGES3 [nucleoplasm]

Physical Entity

AHR:TCDD:2xHSP90AB1:AIP:PTGES3 [nucleoplasm] (Homo sapiens)

Activity

nuclear receptor activity (GO:0004879)

Authored

Jassal, B (2016-08-30)

Reviewed

D'Eustachio, P (2016-10-11)

Hill, DP (2025-08-13)

Created

Jassal, B (2016-08-30)

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