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AHR:TCDD binds ARNT
Stable Identifier
R-HSA-8937177
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Aryl hydrocarbon receptor signalling (Homo sapiens)
AHR:TCDD binds ARNT (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Ligand-bound aryl hydrocarbon receptor (AHR:TCDD) disassociates from the chaperone subunits to then dimerise with the aryl hydrocarbon receptor nuclear translocator (ARNT) (Lees & Whitelaw 1999).
Literature References
PubMed ID
Title
Journal
Year
10409767
Multiple roles of ligand in transforming the dioxin receptor to an active basic helix-loop-helix/PAS transcription factor complex with the nuclear protein Arnt
Lees, MJ
,
Whitelaw, ML
Mol. Cell. Biol.
1999
Participants
Input
AHR:TCDD [nucleoplasm]
(Homo sapiens)
ARNT, ARNT2 [nucleoplasm]
(Homo sapiens)
Output
AHR:TCDD:ARNT [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Aryl hydrocarbon receptor signalling (Homo sapiens)
Orthologous Events
AHR:TCDD binds ARNT (Bos taurus)
AHR:TCDD binds ARNT (Canis familiaris)
AHR:TCDD binds ARNT (Drosophila melanogaster)
AHR:TCDD binds ARNT (Gallus gallus)
AHR:TCDD binds ARNT (Mus musculus)
AHR:TCDD binds ARNT (Rattus norvegicus)
AHR:TCDD binds ARNT (Sus scrofa)
AHR:TCDD binds ARNT (Xenopus tropicalis)
Authored
Jassal, B (2016-08-30)
Reviewed
D'Eustachio, P (2016-10-11)
Created
Jassal, B (2016-08-30)
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