Reactome | AHRR binds ARNT

AHRR binds ARNT

Stable Identifier

R-HSA-8936851

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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The aryl hydrocarbon receptor repressor (AHRR) is predominantly localised in the nucleus of cells (Kanno et al. 2007) and can bind AHR nuclear translocator (ARNT). The resultant AHRR:ARNT complex can compete with AHR:ARNT for binding to the xenobiotic response element (XRE) on target genes such CYP1A1 (Evans et al. 2008, Hahn et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
17980155	Identification of intracellular localization signals and of mechanisms underlining the nucleocytoplasmic shuttling of human aryl hydrocarbon receptor repressor Kanno, Y, Miyama, Y, Takane, Y, Nakahama, T, Inouye, Y	Biochem. Biophys. Res. Commun.	2007
18000031	Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator Evans, BR, Karchner, SI, Allan, LL, Pollenz, RS, Tanguay, RL, Jenny, MJ, Sherr, DH, Hahn, ME	Mol. Pharmacol.	2008
18848529	Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor Hahn, ME, Allan, LL, Sherr, DH	Biochem. Pharmacol.	2009