The aryl hydrocarbon receptor repressor (AHRR) is predominantly localised in the nucleus of cells (Kanno et al. 2007) and can bind AHR nuclear translocator (ARNT). The resultant AHRR:ARNT complex can compete with AHR:ARNT for binding to the xenobiotic response element (XRE) on target genes such CYP1A1 (Evans et al. 2008, Hahn et al. 2009).
Sherr, DH, Hahn, ME, Tanguay, RL, Jenny, MJ, Pollenz, RS, Allan, LL, Karchner, SI, Evans, BR
Miyama, Y, Inouye, Y, Takane, Y, Kanno, Y, Nakahama, T
Sherr, DH, Hahn, ME, Allan, LL
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