Reactome | Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter

Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter

Stable Identifier

R-HSA-8936621

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter

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The WDR5-containing histone methyltransferase MLL complex, recruited to the GP1BA promoter via RUNX1 (and possibly GATA1), methylates histone H3 on dimethylated lysine residue K4 (K5 when taking into account the initiator methionine), producing the H3K4me3 mark. The H3K4me3 mark is characteristic of nucleosome associated with transcriptionally active promoters of megakaryocyte-specific genes (Herglotz et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
22777353	Histone arginine methylation keeps RUNX1 target genes in an intermediate state Hussong, H, Herglotz, J, Kolodziej, S, Grez, M, Kuvardina, ON, Kumar, A, Lausen, J	Oncogene	2013

Participants

Input

Output

Participates

as an event of

RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)

Catalyst Activity

histone H3K4 methyltransferase activity of H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]

Physical Entity

H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)

Activity

histone H3K4 methyltransferase activity (GO:0042800)

Orthologous Events

Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Bos taurus)

Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Caenorhabditis elegans)

Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)

Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Drosophila melanogaster)

Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Gallus gallus)

Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Mus musculus)

Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)