Reactome | GUCY2C trimer binds GUCA2A,B

GUCY2C trimer binds GUCA2A,B

Stable Identifier

R-HSA-8936214

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Heat-stable enterotoxin receptor (GUCY2C, STAR) is the receptor for the endogenous peptides guanylin (GUCA2A) and uroguanylin (GUCA2B) and E.coli heat-stable enterotoxin. GUCY2C is an integral membrane protein composed of an extracellular ligand-binding domain, an intracellular domain and a guanylyl cyclase catalytic domain and functions in trimeric form (Vijayachandra et al. 2000). Once activated by its ligands, GUCY2C mediates fluid-ion homeostasis, intestinal inflammation, and cell proliferation in a cGMP-dependent manner (Arshad et al. 2013). In the intestine, salt and fluid secretion is stimulated by E.coli heat-stable enterotoxins through activation of CUCY2C. The endogenous peptides GUCA2A and GUCA2B have structural similarity to these bacterial enterotoxins and function as mediators of Cl- and water secretion in the intestine (Hamra et al. 1993, Forte et al. 1993, Basu et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
11123935	Biochemical characterization of the intracellular domain of the human guanylyl cyclase C receptor provides evidence for a catalytically active homotrimer Srinivasan, N, Somesh, BP, Suguna, K, Vijayachandra, K, Visweswariah, SS, Bhandari, R, Guruprasad, M, Manjunath, UH	Biochemistry	2000
23269669	Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36 Ballal, S, Visweswariah, SS, Arshad, N	J. Biol. Chem.	2013
7902563	Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase Hamra, FK, Smith, CE, Eber, SL, Freeman, RH, Forte, LR, Krause, WJ, Tompkins, JA, Chin, DT, Pidhorodeckyj, NV, Fok, KF	Proc. Natl. Acad. Sci. U.S.A.	1993
8390480	Guanylin stimulation of Cl- secretion in human intestinal T84 cells via cyclic guanosine monophosphate Turner, JT, Eber, SL, Freeman, RH, Currie, MG, Forte, LR, Fok, KF	J. Clin. Invest.	1993
19960363	Receptor guanylyl cyclase C (GC-C): regulation and signal transduction Basu, N, Visweswariah, SS, Arshad, N	Mol. Cell. Biochem.	2010
8095028	The circulating bioactive form of human guanylin is a high molecular weight peptide (10.3 kDa) Forssmann, WG, Adermann, K, Kuhn, M, Schulz-Knappe, P, Gerzer, R, Raida, M, Heim, JM	FEBS Lett.	1993