GUCY2C trimer binds GUCA2A,B

Stable Identifier
R-HSA-8936214
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Heat-stable enterotoxin receptor (GUCY2C, STAR) is the receptor for the endogenous peptides guanylin (GUCA2A) and uroguanylin (GUCA2B) and E.coli heat-stable enterotoxin. GUCY2C is an integral membrane protein composed of an extracellular ligand-binding domain, an intracellular domain and a guanylyl cyclase catalytic domain and functions in trimeric form (Vijayachandra et al. 2000). Once activated by its ligands, GUCY2C mediates fluid-ion homeostasis, intestinal inflammation, and cell proliferation in a cGMP-dependent manner (Arshad et al. 2013). In the intestine, salt and fluid secretion is stimulated by E.coli heat-stable enterotoxins through activation of CUCY2C. The endogenous peptides GUCA2A and GUCA2B have structural similarity to these bacterial enterotoxins and function as mediators of Cl- and water secretion in the intestine (Hamra et al. 1993, Forte et al. 1993, Basu et al. 2010).

Literature References
PubMed ID Title Journal Year
23269669 Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36

Arshad, N, Ballal, S, Visweswariah, SS

J. Biol. Chem. 2013
11123935 Biochemical characterization of the intracellular domain of the human guanylyl cyclase C receptor provides evidence for a catalytically active homotrimer

Vijayachandra, K, Guruprasad, M, Bhandari, R, Manjunath, UH, Somesh, BP, Srinivasan, N, Suguna, K, Visweswariah, SS

Biochemistry 2000
7902563 Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase

Hamra, FK, Forte, LR, Eber, SL, Pidhorodeckyj, NV, Krause, WJ, Freeman, RH, Chin, DT, Tompkins, JA, Fok, KF, Smith, CE

Proc. Natl. Acad. Sci. U.S.A. 1993
8390480 Guanylin stimulation of Cl- secretion in human intestinal T84 cells via cyclic guanosine monophosphate

Forte, LR, Eber, SL, Turner, JT, Freeman, RH, Fok, KF, Currie, MG

J. Clin. Invest. 1993
19960363 Receptor guanylyl cyclase C (GC-C): regulation and signal transduction

Basu, N, Arshad, N, Visweswariah, SS

Mol. Cell. Biochem. 2010
8095028 The circulating bioactive form of human guanylin is a high molecular weight peptide (10.3 kDa)

Kuhn, M, Raida, M, Adermann, K, Schulz-Knappe, P, Gerzer, R, Heim, JM, Forssmann, WG

FEBS Lett. 1993
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