CCBL1 (KAT 1) catalyzes the reaction of phenylalanine and pyruvate to form 3-(indol-3-yl)pyruvate and alanine. The active form of CCBL1 is a homodimer with one molecule of pyridoxal phosphate bound to each monomer (Baran et al. 1994; Han et al. 2009; Rossi et al. 2004). The enzyme's cytosolic localization is inferred from that of recombinant protein overexpressed in transfected cells (Perry et al. 1995).
Baran, H, Kido, R, Okuno, E, Schwarcz, R
Li, J, Li, J, Rizzi, M, Han, Q, Rossi, F
Scholfield, C, Perry, S, King, L, Harries, H, Goldfarb, P, Gibson, G, Lock, T
Cai, T, Robinson, H, Li, J, Tagle, DA, Han, Q
L-phenylalanine:pyruvate aminotransferase activity of PXLP-KYAT1 dimer [cytosol]
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