Reactome | phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine

phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine

Stable Identifier

R-HSA-893593

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine

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CCBL1 (KAT 1) catalyzes the reaction of phenylalanine and pyruvate to form 3-(indol-3-yl)pyruvate and alanine. The active form of CCBL1 is a homodimer with one molecule of pyridoxal phosphate bound to each monomer (Baran et al. 1994; Han et al. 2009; Rossi et al. 2004). The enzyme's cytosolic localization is inferred from that of recombinant protein overexpressed in transfected cells (Perry et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
15364907	Crystal structure of human kynurenine aminotransferase I Rossi, F, Han, Q, Li, J, Li, J, Rizzi, M	J Biol Chem	2004
8294935	Purification and characterization of kynurenine aminotransferase I from human brain Baran, H, Okuno, E, Kido, R, Schwarcz, R	J Neurochem	1994
7883047	Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase Perry, S, Harries, H, Scholfield, C, Lock, T, King, L, Gibson, G, Goldfarb, P	FEBS Lett	1995
19338303	Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K Han, Q, Robinson, H, Cai, T, Tagle, DA, Li, J	J Med Chem	2009