miR-378 binds RUNX1 mRNA

Stable Identifier
R-HSA-8935766
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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miR-378 binds RUNX1 mRNA
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The mature microRNA miR-378a-3p, one of the two single strand products derived from microRNA miR-378 encoded by the MIR378 gene locus, binds the 3'UTR of the RUNX1 mRNA. Since miR-378 does not induce RUNX1 mRNA degradation, it is assumed that miR-378 functions as a component of the nonendonucleolytic RISC. Levels of miR-378 are decreased in triple negative breast cancer (Browne et al. 2016).
Literature References
PubMed ID Title Journal Year
26749280 MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells

Browne, G, Dragon, JA, Hong, D, Messier, TL, Gordon, JA, Farina, NH, Boyd, JR, VanOudenhove, JJ, Perez, AW, Zaidi, SK, Stein, JL, Stein, GS, Lian, JB

Tumour Biol. 2016
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Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Ito, Y  (2016-12-20)
Chuang, LS  (2016-12-20)
Created
Orlic-Milacic, M  (2016-08-15)
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