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MeR206,MeR210-RUNX1 [nucleoplasm]
Stable Identifier
R-HSA-8934750
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
PRMT1 arginine-methylates RUNX1 (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
MeR206,MeR210-RUNX1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01196 RUNX1
Gene Names
RUNX1, AML1, CBFA2
Chain
chain:1-453
Reference Genes
COSMIC (genes):RUNX1 RUNX1
dbSNP Gene:861 RUNX1
ENSEMBL:ENSG00000159216 RUNX1
Participates
as a component of
MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
RUNX1 [plasma membrane]
p-S249,T273,S276-RUNX1 [nucleoplasm]
p-7Y-RUNX1 [nucleoplasm]
RUNX1 [nucleoplasm]
Inferred To
run [nucleoplasm]
(Drosophila melanogaster)
MeR206,MeR210-RUNX1 [nucleoplasm]
(Bos taurus)
MeR206,MeR210-RUNX1 [nucleoplasm]
(Caenorhabditis elegans)
MeR206,MeR210-RUNX1 [nucleoplasm]
(Canis familiaris)
MeR206,MeR210-RUNX1 [nucleoplasm]
(Mus musculus)
MeR206,MeR210-RUNX1 [nucleoplasm]
(Rattus norvegicus)
MeR206,MeR210-RUNX1 [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
omega-N-methyl-L-arginine at 206
Coordinate
206
PsiMod Name
omega-N-methyl-L-arginine
PsiMod Definition
A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine.
Name
omega-N-methyl-L-arginine at 210
Coordinate
210
PsiMod Name
omega-N-methyl-L-arginine
PsiMod Definition
A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine.
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13951 CBFB
1
CBFB [nucleoplasm]
(R-HSA-8865293)
0.872
7
UniProt:Q9H2X6 HIPK2
3
p-HIPK2 [nucleoplasm]
(R-HSA-6799375)
HIPK2 [nucleoplasm]
(R-HSA-3215222)
monoSUMO1-K32-HIPK2 [nucleoplasm]
(R-HSA-4090405)
0.639
4
UniProt:Q00534 CDK6
3
p-T177-CDK6 [nucleoplasm]
(R-HSA-69628)
CDK6 [nucleoplasm]
(R-HSA-141283)
CDK6 [cytosol]
(R-HSA-68336)
0.628
5
UniProt:P17542 TAL1
1
TAL1 [nucleoplasm]
(R-HSA-8956511)
0.623
3
UniProt:Q15723 ELF2
1
ELF2 [nucleoplasm]
(R-HSA-8938898)
0.544
2
UniProt:Q9GZV5 WWTR1
3
WWTR1 [nucleoplasm]
(R-HSA-1629775)
WWTR1 [cytosol]
(R-HSA-1629773)
p-S89-WWTR1 [cytosol]
(R-HSA-2028665)
0.527
2
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
AKT1 [plasma membrane]
(R-HSA-199416)
AKT1 [cytosol]
(R-HSA-58252)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
0.454
2
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