Reactome | MCAT transfers Mal from Mal-CoA to NDUFAB1

MCAT transfers Mal from Mal-CoA to NDUFAB1

Stable Identifier

R-HSA-8933547

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial matrix

ReviewStatus

5/5

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MCAT transfers Mal from Mal-CoA to NDUFAB1

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The ACP (acyl carrier protein) NDUFAB1 is the cofactor protein that covalently binds all fatty acyl intermediates via a phosphopantetheine linkage during the synthesis of fatty acids. Mitochondrial malonyl-CoA-acyl carrier protein transacylase (MCAT, MT) catalyses the transfer of a malonyl moiety from malonyl-CoA (Mal-CoA) to the free thiol group of the phosphopantetheine arm of NDUFAB1, suggesting a possible role in fatty acid biosynthesis in the mitochondrion (Zhang et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12882974	Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein Joshi, AK, Zhang, L, Smith, S	J. Biol. Chem.	2003