Reactome | LYPLA2 hydrolyses PALM-C3,4-GAP43

LYPLA2 hydrolyses PALM-C3,4-GAP43

Stable Identifier

R-HSA-8933328

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Neuromodulin (GAP43) is a protein associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons (Gauthier-Campbell et al. 2004). An acylation/deacylation cycle is necessary to maintain the steady-state subcellular distribution and biological activity of S-acylated proteins and GAP43 is dually palmitoylated at cysteines 3 and 4 (PALM-C3,4-GAP43). Acyl-protein thioesterase 2 (LYPLA2, APT2) is the protein thioesterase involved in the acylation/deacylation cycle for GAP43 (Tomatis et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
21152083	Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43 Tomatis, VM, Daniotti, JL, Gomez, GA, Trenchi, A	PLoS ONE	2010
14978216	Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs Murphy, TH, El-Husseini, Ael-D, Bredt, DS, Gauthier-Campbell, C	Mol. Biol. Cell	2004