Reactome | LSR trimer binds LDL

LSR trimer binds LDL

Stable Identifier

R-HSA-8933258

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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The human lipolysis-stimulated lipoprotein receptor (LSR, LISCH) probably plays a role in the clearance of triglyceride-rich lipoproteins from blood, allowing their subsequent uptake into cells. Its affinity is highest for those lipoproteins most susceptible to lipolysis such as chylomicrons, LDL and VLDL. Human LSR function is inferred from mouse Lsr expression, functional and gene silencing studies (Yen et al. 1999, Mesli et al. 2004, Yen et al. 2008). Lsr inactivation in mice during embryogenesis resulted in death and indicated expression of Lsr was critical for liver and embryonic development (Mesli et al. 2004). This reaction shows LSR binding LDL.

Literature References

PubMed ID	Title	Journal	Year
18644789	Lipolysis stimulated lipoprotein receptor: a novel molecular link between hyperlipidemia, weight gain, and atherosclerosis in mice Yen, FT, Roitel, O, Bonnard, L, Notet, V, Pratte, D, Stenger, C, Magueur, E, Bihain, BE	J. Biol. Chem.	2008
10224102	Molecular cloning of a lipolysis-stimulated remnant receptor expressed in the liver Yen, FT, Masson, M, Clossais-Besnard, N, André, P, Grosset, JM, Bougueleret, L, Dumas, JB, Guerassimenko, O, Bihain, BE	J. Biol. Chem.	1999
15265030	Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to 14.5 days of gestation Mesli, S, Javorschi, S, Bérard, AM, Landry, M, Priddle, H, Kivlichan, D, Smith, AJ, Yen, FT, Bihain, BE, Darmon, M	Eur. J. Biochem.	2004