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IWS1 [nucleoplasm]
Stable Identifier
R-HSA-8932911
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Protein IWS1 homolog, IWS1_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
Abortive termination of elongation after arrest (Homo sapiens)
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
Elongating transcript encounters a lesion in the template (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
Resumption of elongation after recovery from pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription Elongation (Homo sapiens)
Addition of nucleotides leads to transcript elongation (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
Formation of RNA Pol II elongation complex (Homo sapiens)
Recruitment of elongation factors to form elongation complex (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
Separation of elongating transcript from template (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
IWS1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96ST2 IWS1
Gene Names
IWS1, IWS1L
Chain
chain:1-819
Reference Genes
BioGPS Gene:55677 IWS1
COSMIC (genes):IWS1 IWS1
CTD Gene:55677 IWS1
dbSNP Gene:55677 IWS1
ENSEMBL:ENSG00000163166 IWS1
HGNC:25467 IWS1
KEGG:hsa:55677 IWS1
Monarch:55677 IWS1
NCBI Gene:55677 IWS1
UCSC:Q96ST2 IWS1
Reference Transcript
RefSeq:NM_017969.2 IWS1
Other Identifiers
11717669_a_at
16902502
224768_PM_at
224768_at
224775_PM_at
224775_at
2574885
2574888
2574889
2574892
2574893
2574894
2574898
2574899
2574902
2574904
2574906
2574908
2574909
2574910
2574912
2574913
2574918
2574919
2574920
2574921
2574922
2574923
2574924
2574925
2574926
2574932
2574933
2574935
2574936
2574937
45816_at
55677
8055021
90272_at
A_19_P00321761
A_23_P165574
A_33_P3269134
GE55887
GO:0005515
GO:0005634
GO:0005654
GO:0006325
GO:0006338
GO:0006397
GO:0006913
GO:0008380
GO:0010793
GO:0016071
GO:0016973
GO:0043226
GO:0050684
GO:0051028
GO:0140673
HMNXSV003009336
HMNXSV003038912
HMNXSV003056097
Hs.5570.0.A1_3p_at
Hs.5570.0.A1_3p_x_at
Hs.5570.0.A2_3p_at
ILMN_1747241
PH_hs_0022439
TC02002281.hg
TC02002282.hg
TC02004558.hg
TC02004559.hg
p20930
Participates
as an output of
Elongating transcript encounters a lesion in the template (Homo sapiens)
as a component of
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
as an input of
Recruitment of elongation factors to form elongation complex (Homo sapiens)
Inferred To
Iws1 [nucleoplasm]
(Mus musculus)
Iws1 [nucleoplasm]
(Rattus norvegicus)
iws1 [nucleoplasm]
(Schizosaccharomyces pombe)
iws1 [nucleoplasm]
(Xenopus tropicalis)
SPN1 [nucleoplasm]
(Saccharomyces cerevisiae)
IWS1 [nucleoplasm]
(Bos taurus)
IWS1 [nucleoplasm]
(Caenorhabditis elegans)
IWS1 [nucleoplasm]
(Canis familiaris)
IWS1 [nucleoplasm]
(Dictyostelium discoideum)
IWS1 [nucleoplasm]
(Gallus gallus)
IWS1 [nucleoplasm]
(Sus scrofa)
Dmel\CG9915 [nucleoplasm]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENSP00000295321
,
ENST00000295321
OpenTargets
ENSG00000163166
HPA
ENSG00000163166-IWS1
PRO
Q96ST2
Pharos - Targets
Q96ST2
GlyGen
Q96ST2
PDB
6EMR
,
6ZV4
,
6ZV1
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00267 SUPT5H
1
p-SUPT5H [nucleoplasm]
(R-HSA-3009372)
0.527
2
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