Lysosomal amino acid transporter 1 homolog (PQLC2) is a lysosomal membrane-associated protein that mediates the efflux of the cationic amino acids L-Arg, L-His and L-Lys from the lysosomal lumen to the cytosol, contributing to their homeostasis in cells. PQLC2 belongs to a family of heptahelical membrane proteins, together with the founding member cystinosin, the lysosomal cystine exporter defective in cystinosis. The family are characterised by a duplicated motif termed the PQ loop (Jezegou et al. 2012).
Kieffer-Jaquinod, S, Llinares, E, Andre, B, Chadefaux-Vekemans, B, Anne, C, Sagné, C, Aupetit, J, Jézégou, A, Journet, A, Debacker, C, O'Regan, S, Gasnier, B, Chabli, A
basic amino acid transmembrane transporter activity of PQLC2 [lysosomal membrane]
© 2022 Reactome
