Lysosomal amino acid transporter 1 homolog (PQLC2) is a lysosomal membrane-associated protein that mediates the efflux of the cationic amino acids L-Arg, L-His and L-Lys from the lysosomal lumen to the cytosol, contributing to their homeostasis in cells. PQLC2 belongs to a family of heptahelical membrane proteins, together with the founding member cystinosin, the lysosomal cystine exporter defective in cystinosis. The family are characterised by a duplicated motif termed the PQ loop (Jezegou et al. 2012).
Jézégou, A, Llinares, E, Anne, C, Kieffer-Jaquinod, S, O'Regan, S, Aupetit, J, Chabli, A, Sagné, C, Debacker, C, Chadefaux-Vekemans, B, Journet, A, Andre, B, Gasnier, B
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