NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)

Stable Identifier
R-HSA-8932765
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)
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NSUN6 methylates position 5 of the cytosine ring of cytidine-72 in the acceptor stem of tRNA(Cys) and tRNA(Thr) (Haag et al. 2015). As the reaction occurs in the cytoplasm and requires the 3' CCA on the tRNA substrates, it is believed to occur late in tRNA biogenesis

Literature References
PubMed ID Title Journal Year
26160102 NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs

Haag, S, Warda, AS, Kretschmer, J, Günnigmann, MA, Höbartner, C, Bohnsack, MT

RNA 2015
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity
Catalyst Activity
Title
tRNA (cytosine-5-)-methyltransferase activity of NSUN6 [cytosol]
Physical Entity
NSUN6 [cytosol]
Activity
tRNA (cytosine-5-)-methyltransferase activity (0016428)
Authored
May, B  (2016-07-28)
Reviewed
Bohnsack, MT  (2016-08-10)
Created
May, B  (2016-07-28)