NSUN6 methylates position 5 of the cytosine ring of cytidine-72 in the acceptor stem of tRNA(Cys) and tRNA(Thr) (Haag et al. 2015). As the reaction occurs in the cytoplasm and requires the 3' CCA on the tRNA substrates, it is believed to occur late in tRNA biogenesis
Haag, S, Warda, AS, Kretschmer, J, Günnigmann, MA, Höbartner, C, Bohnsack, MT
tRNA (cytosine-5-)-methyltransferase activity of NSUN6 [cytosol]
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