Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
WTIP [cytosol]
Stable Identifier
R-HSA-8932477
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Wilms tumor protein 1-interacting protein, WTIP_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
WTIP [cytosol] (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
WTIP [cytosol] (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
WTIP [cytosol] (Homo sapiens)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
WTIP [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
WTIP [cytosol] (Homo sapiens)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
WTIP [cytosol] (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
WTIP [cytosol] (Homo sapiens)
Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
VBC complex (with or without LIMD1) [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
WTIP [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
WTIP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:A6NIX2 WTIP
Gene Names
WTIP
Chain
chain:1-430
Reference Genes
BioGPS Gene:126374 WTIP
COSMIC (genes):WTIP WTIP
CTD Gene:126374 WTIP
dbSNP Gene:126374 WTIP
ENSEMBL:ENSG00000142279 WTIP
HGNC:20964 WTIP
KEGG:hsa:126374 WTIP
Monarch:126374 WTIP
NCBI Gene:126374 WTIP
OMIM:614790 WTIP
UCSC:A6NIX2 WTIP
Reference Transcript
RefSeq:NM_001080436.1 WTIP
Other Identifiers
11721578_at
126374
16860766
227411_PM_at
227411_at
2688745
3829818
3829819
3829820
3829821
3829822
3829823
3829824
3829826
3829827
3829828
3829829
3829830
3829831
3829832
3829833
3829834
3829835
3829836
3829837
3829838
3829840
3829841
3829843
3829844
3829845
3829846
3829847
49384_at
56841_at
8027665
A_33_P3381948
GE537786
GO:0000932
GO:0001666
GO:0003714
GO:0005515
GO:0005634
GO:0005667
GO:0005737
GO:0005912
GO:0006355
GO:0007010
GO:0022604
GO:0030030
GO:0031047
GO:0035195
GO:0035278
GO:0035331
GO:0043226
GO:0045892
GO:0046872
GO:0060090
GO:0070161
GO:0140110
HMNXSV003015497
HMNXSV003050065
Hs.39384.1.A1_3p_at
Hs.39384.1.A1_3p_x_at
ILMN_1801223
ILMN_2386291
PH_hs_0031737
TC19000445.hg
Participates
as a candidate of
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
Inferred To
wtip [cytosol]
(Xenopus tropicalis)
WTIP [cytosol]
(Bos taurus)
WTIP [cytosol]
(Canis familiaris)
WTIP [cytosol]
(Gallus gallus)
WTIP [cytosol]
(Sus scrofa)
Wtip [cytosol]
(Mus musculus)
Wtip [cytosol]
(Rattus norvegicus)
jub [cytosol]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENSP00000466953
,
ENST00000590071
OpenTargets
ENSG00000142279
HPA
ENSG00000142279-WTIP
PRO
A6NIX2
Pharos - Targets
A6NIX2
HMDB Protein
HMDBP14074
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text