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LIMD1,AJUBA,WTIP
Stable Identifier
R-HSA-8932471
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Regulation of Hypoxia-inducible Factor (HIF) by oxygen (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
VBC complex (with or without LIMD1) [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
LIMD1,AJUBA,WTIP [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
22286099
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity
Nat. Cell Biol.
2012
Participants
members
LIMD1 [cytosol] (Homo sapiens)
candidates
AJUBA [cytosol] (Homo sapiens)
WTIP [cytosol] (Homo sapiens)
Participant Of
hasComponent
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol]
Inferred To
LIMD1,AJUBA,WTIP [cytosol] (Bos taurus)
LIMD1,AJUBA,WTIP [cytosol] (Caenorhabditis elegans)
LIMD1,AJUBA,WTIP [cytosol] (Danio rerio)
LIMD1,AJUBA,WTIP [cytosol] (Drosophila melanogaster)
LIMD1,AJUBA,WTIP [cytosol] (Gallus gallus)
LIMD1,AJUBA,WTIP [cytosol] (Mus musculus)
LIMD1,AJUBA,WTIP [cytosol] (Rattus norvegicus)
LIMD1,AJUBA,WTIP [cytosol] (Sus scrofa)
LIMD1,AJUBA,WTIP [cytosol] (Taeniopygia guttata)
LIMD1,AJUBA,WTIP [cytosol] (Xenopus tropicalis)
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