KEAP1 facilitates ubiquitination of NFE2L2

Stable Identifier
R-HSA-8932351
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The KEAP1:CUL3:RBX1 E3-ubiquitin ligase complex is a negative regulator of Nuclear factor erythroid 2-related (NFE2L2). In the absence of oxidative stress this E3-ubiquitin ligase complex is bound to NFE2L2 and targets it for ubiquitination (Cullinan et al. 2004).

Literature References
PubMed ID Title Journal Year
15367669 The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

Cullinan, SB, Gordan, JD, Jin, J, Harper, JW, Diehl, JA

Mol. Cell. Biol. 2004
15282312 Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Kobayashi, A, Kang, MI, Okawa, H, Ohtsuji, M, Zenke, Y, Chiba, T, Igarashi, K, Yamamoto, M

Mol. Cell. Biol. 2004
Participants
Participates
Catalyst Activity

ubiquitin protein ligase activity of KEAP1:CUL3:RBX1:NFE2L2 [cytosol]

This event is regulated
Negatively by
Regulator
Orthologous Events
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