Reactome | KEAP1 facilitates ubiquitination of NFE2L2

KEAP1 facilitates ubiquitination of NFE2L2

Stable Identifier

R-HSA-8932351

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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Cellular responses to external stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - Cytoprotection by HMOX1 (Homo sapiens)
      - Regulation of HMOX1 expression and activity (Homo sapiens)
        
        ROS sensing by NFE2L2 (Homo sapiens)
        
        KEAP1 facilitates ubiquitination of NFE2L2 (Homo sapiens)

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KEAP1 facilitates ubiquitination of NFE2L2

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The KEAP1:CUL3:RBX1 E3-ubiquitin ligase complex is a negative regulator of Nuclear factor erythroid 2-related (NFE2L2). In the absence of oxidative stress this E3-ubiquitin ligase complex is bound to NFE2L2 and targets it for ubiquitination (Cullinan et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15367669	The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase Cullinan, SB, Gordan, JD, Jin, J, Harper, JW, Diehl, JA	Mol. Cell. Biol.	2004
15282312	Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 Kobayashi, A, Kang, MI, Okawa, H, Ohtsuji, M, Zenke, Y, Chiba, T, Igarashi, K, Yamamoto, M	Mol. Cell. Biol.	2004