PKC phosphorylates NFE2L2

Stable Identifier
R-HSA-8932284
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PKC phosphorylates NRF2
ReviewStatus
5/5
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PKC phosphorylates NFE2L2
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In response to oxidative stress, protein kinase C (PKC) phosphorylates NFE2L2 (NRF2) at residue serine 40 (Ser-40). It has been demonstrated that NRF2 phosphorylation at Ser-40 facilitates its nuclear translocation (Huang et al. 2002).
Literature References
PubMed ID Title Journal Year
12198130 Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

Huang, HC, Nguyen, T, Pickett, CB

J. Biol. Chem. 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

diacylglycerol-dependent, calcium-independent serine/threonine kinase activity of PRKCD [cytosol]

Physical Entity
PRKCD [cytosol] (Homo sapiens)
Activity
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (GO:0004699)
This event is regulated
Positively by
Regulator
ROS [cytosol]
Inferred From
PKC phosphorylates Nrf2 (Rattus norvegicus)
Authored
Garapati, P V  (2016-07-22)
Reviewed
Somers, J  (2021-01-23)
Cuadrado, A  (2022-02-23)
Created
Garapati, P V  (2016-07-22)
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