PKC phosphorylates NFE2L2

Stable Identifier
R-HSA-8932284
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PKC phosphorylates NRF2
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PKC phosphorylates NFE2L2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In response to oxidative stress, protein kinase C (PKC) phosphorylates NFE2L2 (NRF2) at residue serine 40 (Ser-40). It has been demonstrated that NRF2 phosphorylation at Ser-40 facilitates its release from the cytoplasmic anchor KEAP1 and triggers its nuclear translocation (Huang et al. 2002).

Literature References
PubMed ID Title Journal Year
12198130 Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

Huang, HC, Nguyen, T, Pickett, CB

J. Biol. Chem. 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein kinase C activity of PRKCD [cytosol]

Physical Entity
PRKCD [cytosol] (Homo sapiens)
Activity
protein kinase C activity (GO:0004697)
This event is regulated
Positively by
Regulator
ROS [cytosol]
Summation

Excess accumulation of reactive oxygen species in the cilium can result in the misfolding of cilia proteins leading to shortening of the cilia (Lam HC et al. 2013, Kim JI et al. 2013).

Inferred From
PKC phosphorylates Nrf2 (Rattus norvegicus)
Authored
Garapati, P V  (2016-07-22)
Reviewed
Somers, J  (2021-01-23)
Created
Garapati, P V  (2016-07-22)
Cite Us!