METTL22 transfers 3xCH3 from 3xAdoMet to KIN

Stable Identifier
R-HSA-8932275
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
METTL22 transfers 3xCH3 from 3xAdoMet to KIN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
METTL22 trimethylates lysine-135 of DNA/RNA-binding protein KIN17 (KIN) (Cloutier et al. 2013)
Literature References
PubMed ID Title Journal Year
23349634 A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity

Blanchette, M, Faubert, D, Cloutier, P, Coulombe, B, Lavallée-Adam, M

PLoS Genet. 2013
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein-lysine N-methyltransferase activity of METTL22 [nucleoplasm]

Physical Entity
METTL22 [nucleoplasm] (Homo sapiens)
Activity
protein-lysine N-methyltransferase activity (GO:0016279)
Orthologous Events
METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Bos taurus)
METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Canis familiaris)
METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Danio rerio)
METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Drosophila melanogaster)
METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Gallus gallus)
METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Mus musculus)
METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Rattus norvegicus)
METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Sus scrofa)
METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Xenopus tropicalis)
Authored
Jupe, S  (2016-06-16)
Reviewed
Falnes, PØ  (2016-10-10)
Created
Jupe, S  (2016-07-22)
Cite Us!