METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8

Stable Identifier
R-HSA-8932221
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8
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Protein N-lysine methyltransferase METTL21A trimethylates lysine-561 of Heat shock cognate 71 kDa protein (HSPA8) and corresponding lysine residues in other Hsp70 isoforms (Jakobsson et al. 2013, Cloutier et al. 2013).
Literature References
PubMed ID Title Journal Year
23349634 A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity

Cloutier, P, Lavallée-Adam, M, Faubert, D, Blanchette, M, Coulombe, B

PLoS Genet. 2013
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
regulation of protein folding (1903332)
Catalyst Activity

protein-lysine N-methyltransferase activity of METTL21A [nucleoplasm]

Physical Entity
METTL21A [nucleoplasm] (Homo sapiens)
Activity
protein-lysine N-methyltransferase activity (GO:0016279)
Orthologous Events
METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Bos taurus)
METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Canis familiaris)
METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Danio rerio)
METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Dictyostelium discoideum)
METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Gallus gallus)
METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Mus musculus)
METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Rattus norvegicus)
METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Saccharomyces cerevisiae)
METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Schizosaccharomyces pombe)
METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Sus scrofa)
METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Xenopus tropicalis)
Authored
Jupe, S  (2016-06-16)
Reviewed
Falnes, PØ  (2016-10-10)
Created
Jupe, S  (2016-07-22)
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