GPAM gene expression is stimulated by RUNX1 and ESR1

Stable Identifier
R-HSA-8932020
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial outer membrane
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GPAM gene expression is stimulated by RUNX1 and ESR1
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GPAM gene expression is cooperatively stimulated by RUNX1 and ESR1, which form a complex and bind the GPAM gene enhancer (Stender et al. 2010). GPAM encodes a glycerol-3-phosphate acyltransferase whose high expression correlates with better overall survival in breast cancer (Brockmoller et al. 2012).

Literature References
PubMed ID Title Journal Year
20547749 Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation

Kraus, WL, Stender, JD, Benner, C, Charn, TH, Kim, K, Chang, KC, Katzenellenbogen, BS, Glass, CK, Komm, B

Mol. Cell. Biol. 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX1:CBFB:ESR1:estrogen:GPAM gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1:CBFB:ESR1:estrogen [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-07-20)
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