GPAM gene expression is stimulated by RUNX1 and ESR1

Stable Identifier
R-HSA-8932020
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial outer membrane
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GPAM gene expression is stimulated by RUNX1 and ESR1
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GPAM gene expression is cooperatively stimulated by RUNX1 and ESR1, which form a complex and bind the GPAM gene enhancer (Stender et al. 2010). GPAM encodes a glycerol-3-phosphate acyltransferase whose high expression correlates with better overall survival in breast cancer (Brockmoller et al. 2012).

Literature References
PubMed ID Title Journal Year
20547749 Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation

Stender, JD, Kim, K, Charn, TH, Komm, B, Chang, KC, Kraus, WL, Benner, C, Glass, CK, Katzenellenbogen, BS

Mol. Cell. Biol. 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX1:CBFB:ESR1:estrogen:GPAM gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1:CBFB:ESR1:estrogen [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Ito, Y  (2016-12-20)
Chuang, LS  (2016-12-20)
Created
Orlic-Milacic, M  (2016-07-20)
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